Chapter 19 - eyelids, claws, anal sacs and ears Flashcards
Are glands of Zeis prominent sebaceous glands or modified sweat glands?
Prominent sebaceous glands
Are glands of Moll prominent sebaceous glands or modified sweat glands?
Modified sweat glands
What is another name for Meibomian glands?
Tarsal glands
Which deep mycoses is most likely to affect the eyelids in cats?
Histoplasma capsulatum
Which oral drug can be used to treat FHV-1 associated blepharitis?
Famciclovir
Which drugs can trigger drug-induced apoptosis in allergic blepharitis?
Potentiated sulphonamides
Penicllins
Cephalosporins
Bilateral ulcerative blepharitis affecting the medial canthi is seen in which breeds of dog?
GSDs
Longhaired Dachs
Toy/minature Poodles
Name two metabolic/nutritional causes of blepharitis?
Zinc-responsive dermatosis
Generic dog food dermatosis
Superficial necrolytic dermatitis
Which breeds of cat are affected by idiopathic blepharitis (‘dirty face’)?
Persians
Himalayans
Periocular vitiligo occurs most commonly in which breed of dog?
Rottweilers
Transient periocular leukotrichia, associated with pregnancy or systemic illness, is seen in which breeds of cat?
Siamese
What is the most common canine eyelid tumour?
Sebaceous adenoma (from Meibomian glands)
What is the most common feline eyelid tumour?
Squamous cell carcinoma
What is a chalazion?
A painless swelling of the Meibomian gland caused by a blockage of its duct and retention of secretions. It looks like a firm, white-yellow nodule.
Leukonychia, when seen in isolation, is suggestive of which disease?
Vitiligo
Which immune-mediated disease, other than SLO, can be localised to the nails?
Lupus erythematosus
Subepidermal bullous dermatoses
Pemphigus vulgaris
Which breeds are predisposed to SLO?
GSDs
Gordon Setters
Are intracellular bacteria a normal or abnormal finding in canine anal sacs?
Normal
What is the most common type of anal sac neoplasia?
Adenocarcinoma
What is the most common endocrine cause of otitis?
Hypothyroidism
Which disease causes tightly adhered hyperkeratotic crusts (gold coloured) on erythematous plaques on the pinnae in cats?
Feline proliferative and necrotising otitis externa
Calcification of connective tissue occurs inside or outside the auricular cartilage?
Outside
Potent surfactants and detergents are often found in what type of ear cleaner?
Ceruminolytic
Which ceruminolytic agent was shown not to cause proliferative middle ear disease?
Squalene
How does EDTA make antibiotics/antiseptics more effective?
Induces changes in cell membrane permeability
Name two ‘soft’ glucocorticoids
Hydrocortisone aceponate
Mometasone furoate
Cystadenomatosis is most common in what signalment of cat?
Males, older age
Abyssinian, Himalayan and Persian and DSH
Is cystadenomatosis associated with viral infection in cats?
No - does not appear to be associated with papillomavirus, feline infectious peritonitis, feline immunodeficiency virus/feline leukemia virus status or other identifiable illnesses.
Cystadenomatosis has been found to primarily affect the preauricular region, concave pinna, concha, tragus and antitragus, and the external ear canal of cats; which non-aural areas can be affected?
Periocular, perioral and perianal regions
Which glands are affected in cystadenomatosis and where are they found?
Modified sweat apocrine glands
- found in the skin surrounding the eyelid margins (Moll’s glands), lip margins and perianal regions, but are most prevalent in and around the ears
What is cerumen made of?
- Fatty secretions from sebaceous and ceruminous glands - triglycerides, sterol esters, fatty acid esters and squalene
- IgG> IgA, IgM
- Squames
Which part of the ear canal contains more ceruminal than sebaceous glands?
Ceruminous glands are more prevalent in the horizontal meatus compared with the vertical meatus, where there are more sebaceous and apocrine glands
Why are the lesions of cystadenomatosis blue/grey in colour?
- Distension of skin
- Pigmentary contributions from hemosiderin and ceroid of the thick acellular or cell-poor fluid filling the cystic lumen
What % of isolates of Pseudomonas aeruginosa from canine OE are MDR?
Up to 92%
Which cytokine is overexpressed in dogs with atopic otitis and otodectic mange and correlates with the otitis severity in atopic dogs?
IL-8
Significant increases in the levels of IL-10 were also overexpressed in atopic otitis but at lower rates
What effect did cleaning with an ethoxydiglycol, capric glycerides, isopropyl alcohol,calendula, tromethamine, glycerin and lipacids cleaner (Sonotix®) have on erythemato-ceruminous OE in dogs with predominantly Malassezia overgrowth?
- It reduced pruritus score, OTIS-3, cytology score and otic secretion score in 7 days and further reduced it in 14 days
- IL-8 also reduced compared to baseline and there was a decrease in free lipids and an increase in bound lipids.
Based on PCR, which three bacteria were most abundant in healthy ears of dogs?
Cutibacterium acnes (previously known as Propionibacterium acnes),Staphylococcus pseudintermedius, and Streptococcus spp
In dogs with OE, 78.3% had microbial overgrowth on PCR testing; was bacterial or fungal overgrowth more common?
- 62.78% bacterial overgrowth
- 8.5% fungal overgrowth
- 7.0% had both
What type of bacteria is Finegoldia magna?
Gram +ve anaerobic coccus
Found in healthy ears of dogs on PCR but much more abundant in OE
Oclacitinib has been shown to be effective at managing ear tip ulcerative dermatitis; which differential diagnoses should be ruled out before starting treatment?
Infectious cases - leishmaniosis, bartonellosis (Bartonella henselae), Rickettsia rickettsia
What % of myringotomy aspirates can be contaminated by material from the external ear canal and how can this be reduced?
68%
By performing a ventral approach (special table etc. needed)
What are the benefits of CO2 laser surgery of proliferative ear canal/pinnal lesions compared to traditional surgery?
- Ability to sculpt rather than just excise
- Sterilisation of the wound bed
- Ablates sensory nerve endings, helping to reduce postoperative pain
Which special stain has been shown to identify biofilm?
PAS - stains polysaccheride matrix
When staining otic discharge with PAS, which findings are suggestive of biofilm associated infection?
- Presence of three or more microbial aggregates
- Presence of high-density material
- Extracellular staining and the presence of discretely stained matrix
What are the gold standard techniques to identify biofilm?
- Confocal laser scanning microscopy (CLSM) or scanning electron microscopy (SEM)
- Fluorescence in-situ hybridisation (FISH)
What are the benefits of referral for cases of chronic OE?
- Number of episodes of otitis was reduced
- Median time between recurrence of otitis reduced
- Proliferative pathological change was significantly reduced
- Better outcome if referral occurred within 6 months
- Have equipment to perform effective, deep cleaning of the external ear canal
- Access to advanced imaging modalities
- Colleagues in associated fields such as neurology and soft tissue surgery, for specialist input
What is the pattern of epithelial migration on the tympanic membrane?
Centrifugal
Which ear treatment has been shown to exhibit the fastest diffusion through the cerumen lipids?
Aurizon