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Sarah - Mulller and Kirk > Chapter 14 - Keratinisation disorders > Flashcards

Chapter 14 - Keratinisation disorders Flashcards

1
Q

What is the most common acquired keratinisation defect?

A

Callus

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2
Q

Define xerosis

A

Dry skin

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3
Q

What is the optimal stratum corneum water concentration?

A

20-35%

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4
Q

Is salicylic acid (0.1-2%) keratolytic, keratoplastic or both?

A

Keratoplastic (lytic at 3-6%)

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5
Q

Is benzoyl peroxide keratolytic, keratoplastic or both?

A

Keratolytic

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6
Q

Is tar keratolytic, keratoplastic or both?

A

Both

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7
Q

Is selenium sulfide keratolytic, keratoplastic or both?

A

Both

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8
Q

What effect do luekotriene B4 and prostoglandin E2 have on basal epidermal cells?

A

Increase DNA synthesis and stimulate epidermal proliferation

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9
Q

Vitamin A responsive dermatosis is reported in which breeds of dog?

A

Cocker spaniels, Labradors, Min. Schuazers and Gordon Setters

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10
Q

Name four diseases that can cause nasodigital hyperkeratosis

A 
Distemper
Leishmaniasis
PF
SLE
Zinc-responsive dermatosis
Drug reaction
Generic dog food dermatosis
Cutaneous lymphoma
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11
Q

Why does alopecia occur with canine tail gland hyperplasia?

A

Friction and compression of hair follicles by hyperplastic glands

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12
Q

At which anatomical site does scaling typically start with thymoma associated exfoliative dermatitis?

A

Head and pinnae

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13
Q

With thymoma associated exfoliative dermatitis, is the hydropic interface dermatitis seen on histopathology cell-rich or cell-poor?

A

Cell-poor

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14
Q

Carcinoid syndrome in dogs, which causes erythroderma, is associated with which tumours?

A

Pulmonary adenocarcinoma and intestinal carcinoma

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15
Q

In vitamin A responsive dermatosis, where is hyperkeratosis most prominent on histopathology?

A

Follicular ostea

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16
Q

What is the age of onset of feline acne?

A

4 years (6m -14y)

17
Q

List the types of lesions seen in feline acne in order of frequency of occurrence

A
  1. Comedones (73%)
  2. Alopecia (68%)
  3. Crusts (55%)
  4. Papules (45%)
  5. Erythema (41%)
  6. Pruritus (35%)
  7. Pustules (9%)
  8. Nodules/fistulas (9%)
  9. Scarring (4.5%)
18
Q

How common are bacterial and Malassezia overgrowth in cats with acne?

A

Malassezia 18%

Bacterial 45%

19
Q

Name three histopath features of feline acne

A
  1. Lymphoplasmacytic periductal inflammation (86%)
  2. Sebaceous gland duct dilatation (73%)
  3. Follicularkeratosis with plugging and dilatation (59%)
  4. Epitrichial gland occlusion and dilatation (32%)
  5. Folliculitis (27%)
  6. Pyogranulomatous sebaceous adenitis (23%)
  7. Furunculosis (23%)
20
Q

Transglutaminase is dependent on which mineral/ion?

A

Calcium

21
Q

Absence of NIPAL4 or PNPLA1, as in ichthyosis of American bulldogs and golden retrievers, leads to loss of which epidermal structure?

A

Corneocyte lipid envelope

AND thinning of the cornified envelope

Sarah - Mulller and Kirk (14 decks)

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