Chapter 186- Systemic And Topical Antibiotics Part Ii

Question 1

Quinupristin- Dalfopristin are streptogramin antibiotics combined in a fixed ratio of ____

Answer 1

3:7

Question 2

Most common side effect of quinupristin-dalfopristin

Answer 2

Phlebitis 75%

Question 3

Derived from fermentation of Streptomyces roseoporus

Answer 3

Daptomycin

Question 4

Approved for treatment of MRSA, VRE, and penicillin resistant pneumonia

Answer 4

Daptomycin

Question 5

The primary serious adverse event of daptomycin is

Answer 5

Myopathy

Question 6

Carbapenem member of family reserved for polymicrobial infections not sensitive to agents with more narrow spectra of activity

Answer 6

Ertapenem

Question 7

Glycycline antibiotic with broad spectrum activity that is indicated for treatment of complicated SSTIs

Answer 7

Tigecycline

Question 8

MOA of Tigecycline (similar to tetracycline)

Answer 8

Binds to 30S ribosomal binding subunit

Question 9

Topical agent derived from Pseudomonas fluorescens

Answer 9

Mupirocin (Pseudomonic acid A)

Question 10

MOA of Mupirocin

Answer 10

Reversibly binds to isoleucyl transfer RNA synthetase and inhibits protein synthesis

Question 11

Avoid application with ____ to large open wounds to prevent toxic absorption

Answer 11

Polyethylene glycol

Question 12

Semisynthetic pleuromutilin antibiotic isolated from Clitophilus scyphoides

Answer 12

Retapamulin

Question 13

MOA of Retapamulin

Answer 13

Inhibits peptidyl transferase and partial inhibition of binding of initiator transfer RNA to P site of ribosome

Question 14

Retapamulin is approved for treatment of impetigo in patients older than ___

Answer 14

9mos

Question 15

Polypeptide antibiotic isolated from Tracy- I strain of Bacillus subtilis

Answer 15

Bacitracin

Question 16

MOA of Bacitracin A

Answer 16

Interferes with bacterial cell wall synthesis

Question 17

Risk of ACD is highest with this triple combination antibiotic

Answer 17

Bacitracin
Polymyxin B
Neomycin

Question 18

Topical antibiotic derived from spore forming soil aerobe Bacillus polymyxa

Answer 18

Polymyxin B

Question 19

Isolated from Streptomyces fradiae

Answer 19

Neomycin

Question 20

Isolated from Micromonospora purpurea

Answer 20

Gentamicin

Question 21

Inhibits bacterial protein synthesis translocation by interruption of elongation factor G

Answer 21

Fusidic acid

Question 22

Adverse effects of fusidic acid

Answer 22

ACD

Question 23

Adverse effects of silver sulfadiazine

Answer 23

Transient leukopenia

Question 24

All topical antibiotics are Category B except for

Answer 24

Bacitracin (C)
Polymyxin B (C)
Gentamicin (C)
Neomycin (D)