Chapter 18 Flashcards
Difference of circulatory system and cardiovascular system
Circulatory: heart blood vessels and blood
cardiovascular system: heart and vessels
Three functions of the circulatory system
Transportation of oxygen nutrients and carries a metabolic waste
Protection inflammation limiting spread of infection
Regulation stabilize the fluid in the body
Difference between formed elements and plasma
Plasma matrix clear yellow fluid
Formed elements cells and cell fragments
Main components of plasma
Water proteins nutrients electrolytes
Functions of plasma
Clotting defense and transport of other solutes
Difference between serum and plasma
Serum does not have a clotting protein fibrinogen
Three major plasma proteins
Albumin gamma globulins fibrinogen
Function of albumin
Most abundant transport various solutes and buffer the pH of the plasma
Function of gamma globulin’s
Salute transport clotting immunity
Function of fibrinogen
Sticky protein that forms the framework of a blood clot
Organ that produces most plasma proteins
Liver
Viscosity
Resistance of a fluid to flow resulting from cohesion of particles thickness or stickiness of a fluid
Osmolarity
Rate of reabsorption nourish surrounding cells transfer of fluids
Hemopoiesis
Production of blood and it’s formed elements
Two major types of hemopoietic tissues in adults
Yolk sac in membrane
Red bone marrow
Difference between lymphoid hemopoiesis and myeloid hemopoiesis
Blood formation in the bone marrow and lymphatic organs
Two functions of erythrocytes
Pick up oxygen from lungs and deliver tissues elsewhere
Pick up carbon dioxide from the tissues and unload it in the lungs
Lack of mitochondria in erythrocyte
Prevents from consuming the oxygen they must transport
Large amount of hemoglobin in the cytoplasm
Aids and transport of carbon dioxide and buffering blood pH
Cytoskeletal proteins in erythrocytes
Give membrane resilience and durability
Biconcave shape of erythrocytes
promotes Quick diffusion of oxygen
Hemoglobin molecule
4 protein chains globulins 2 Alpha chains 2 beta chains
heme finds oxygen to an iron atom at its center
iron key nutritional requirement
Two gases HB transport
Oxygen binds to iron atom at its center at heme
Carbon dioxide binds to go globin moiety
Erythropoiesis
Erythrocyte production 3 to 5 days
Four major developments in erythropoiesis
Reduction in cell size
Increase in cell number
Synthesis of hemoglobin
Loss of nucleus and other organelles
Erythropoietin
Hormone secreted by the kidneys stimulates erythrocyte colony forming units to transform into an erythroblast
Nutrients required for erythropoiesis
Iron vitamin B 12 folic acid cell division and DNA synthesis
Vitamin C and copper synthesize hemoglobin
Relationship between erythropoiesis and hypoxemia
Oxygen deficiency in blood
Causes of hypoxemia
Low oxygen in atmosphere
Abrupt increase in oxygen consumption
Lifetime of erythrocytes
120 days
Erythrocytes cause of death
Old cells become trapped broken up and destroyed
Erythrocyte graveyard
Spleen
Hemolysis
Rupture of RBCs releases hemoglobin and leaves empty plasma membrane’s
Erythrocyte membrane fragments
Easily digested by macrophages in the liver and spleen
Polycythemia
Dehydration because water is lost from the bloodstream erythrocytes remain and become abnormally concentrated
Hemorrhagic anemia
Bleeding results from kidney failure
Hemolytic anemia
RBC destruction trauma hemophilia menstruation ulcer
Iron deficiency anemia
Dietary deficiency of requirements for erythropoiesis
Pernicious anemia
Inadequate vitamin B 12 absorption
Aplastic hypoplastic anemia
Reduced physical activity gastric atrophy
Sickle cell anemia
Low oxygen concentration intense pain in oxygen starved tissues
Leukopenia
When white blood cell is below normal count arsenic mercury poisoning radiation sickness measles mumps and chickenpox polio
Leukocytosis
Count above 10,000 indicates infection allergy dehydration or emotional disturbances
Leukemia
Cancer of the hemopoietic tissues produces high number of circulating leukocytes
Thrombocytopenia
Interference with platelet production which produces dangerous platelet deficiency
Two main categories of leukocytes
Granulocytes
Agranulocytes
Granulocytes
Neutrophils eosinophils basophils
Agranulocytes
Monocytes lymphocytes
Neutrophils
Most abundant 3 to 5 lobes red granules destroyed bacteria
Lymphocytes
Second most abundant dark round violet color nucleus destroy cancer cells cells with viruses and secretes antibodies
Monocytes
Third most abundant horseshoe nucleus no granules macrophages phagocytize dead cells
Eosinophils
Fourth most abundant two large lobes orange pink granules destroy parasites such as worms
Basophil’s
Least abundant nucleus S shaped dark violet granules secrete histamine
Leukopoiesis
Production of white blood cells
myeloblast
Neutrophils Eosinophils basophil’s
Monoblasts
Monocytes
Lymphoblasts
Produce all lymphocyte types
Platelets
Small fragments of marrow cells
Thrombopoiesis
Production of platelets is a division of hemopoiesis
What hormone stimulates thrombopoiesis
thrombopoietin
Precursor cells that give rise to platelets
Megakaryocyte
Seven functions of platelets
Secrete chemicals stick together to form plugs secrete Clotting factors dissolve blood clots secrete chemicals to sites of information internalize and destroy bacteria secrete growth factors
Vascular spasm
Immediate protection against blood loss prompt constriction of broken blood vessel
Platelet plug formation
Pseudopods contract and drawl the walls of the vessel together reduce or stop minor bleeding
Coagulation
Important for it not to clot in the absence of vessel damage
Procoagulants
Clotting factors produced by the liver
Fibrinogen
Plasma protein
Fibrin
Sticky protein that adheres to the walls of a vessel
Thrombin
Converts fibrinogen into shorter strands of fibrin monomer
Extrinsic
Uses clotting factors from sources external to the blood
Intrinsic
uses only clotting factors found in the blood itself
Clot retraction
Adhere to strands of fiber in and contract draws edges of broken vessels together
Platelet derived growth factor
Fibroblasts invade clot and produce fibrous connective tissue to repair the damaged blood vessels
Fibrinolysis
Small cascade of reactions with a positive feedback component
Plasmin
Fibrin dissolving enzyme that breaks up the clot
Platelet repulsion
Platelets do not adhere to the smooth endothelium of healthy blood vessels
Dilution
Small amounts of thrombin form in plasma thrombin diluted quickly clot has little chance to form
Anticoagulants
Thrombin formation is suppressed by anticoagulants that are present in the plasma
Hemophilia
A family of hereditary diseases characterized by deficiencies of one factor or another
Hematoma
Masses of clotted blood in the tissues
Thrombosis
The abnormal clotting of blood in an unbroken blood vessel problematic in old-age
Thrombus
Clot that grows large enough to obstruct a small vessel or a piece of it may break loose and begin to travel in the bloodstream
Embolus
Can lodge in a small artery and block blood flow from that point on