Chapter 16 - Treatments Flashcards
Psychosurgery
- Prefrontal lobotomy for Schiz
- Cut nerves from frontal lobe to thalamus
Thorazine (Chlorpromazine)
- Dopamine antagonist
- Works on positive symptoms
Tardive Dyskenesia
Involuntary facial movements and grimacing
Clozapine
- Acts on dopamine and serotonin
- Works on ‘negative symptoms’
- No tardive dyskenesia
- Dizziness, nausea, sedation, seizures, irregular heartbeat
Token economies
- Reward/punishment changes behaviour
- Does not cure
- Criticized for dehumanizing and benefits institution more than patient
Anxiety disorder
- GAD - chronic, high level
- OCD, PTSD, Hypochondriasis are no longer in DSM-V
- Learned by classical cond. (albert/rat), maintained by operant cond. (avoid feared stim)
- Genes for neuroticism lead to anxiety and major depression
Anxiety Sensitivity
Fear of anxiety itself
Flooding
- “face your fears”; see that nothing horrible happened - classical and operant conditioning to extinction
Systematic desensitization
- gradually exposing to stimulus; fear replaced with relaxation
- Strong placebo
Bipolar disorder
Manic - at least a week – plus depression
High Norepinephrine
Dopamine receptors are oversensitive
Increased activity in amygdala
Decreased activity in pre-frontal cortex
Sleep deprivation is trigger for manic ep.
Major depressive disorder
Major depressive episode - two weeks (Depressed mood for most of day AND Loss of Interest in normal daily activities – plus 3 more – 5 total)
Low NOREP, DOP, SER
SERT (transporter gene) structured differently
Biology of depression
40% concordance with MZ twins/ 11% with DZ
85% concordance of MZ for bipolar
MAOIs
prevent MAO from breaking down NOREP, DOP, SER
Tricyclics
Block reuptake of SER, NOREP
Mood stabilizers
Lithium carbonate decreases NOR - reduces swings