Chapter 15 - Autonomic Nervous System Flashcards
Parasympathetic
Rest and Digest, Craniosacral, Preganglionic fiber long and postganglionic fiber is short, both synapse release ACh. Preganglionic fiber is lightly myelinated, synapse with ACh to postganglionic nonmyelinated axon. Postganglionic synapses to effector organ (smooth muscle) with ACh
Sympathetic
Fight or Flight, Orginates out of lateral horn of thoracolumbar spinal cord, axon projects through ventral spinal root and nerve to sympathetic ganglion. Lightly myelinated preganglionic axons synapse with nonmyelinated postganglionic and releases ACh. Postganglionic neuron synapses with effector organ and releases Norepinephrine. Can also synapse to Adrenal Medulla to release Epinephrine and Norepinephrine into the blood stream for quicker response.
Autonomic NS
2 neuron chain, preganglionic neuron release ACh, effect is either stimulatory or inhibitory, controls cardiac and smooth muscle and glands
Dual innervation
All visceral organs served by both divisions, but cause opposite effects, maintains homeostasis
Components of a Visceral Reflex
- ) Receptor in Viscera
- ) Visceral Sensory Neuron
- ) Integration Center (preganglionic neuron, dorsal horn interneuron, or within walls of gastrointestinal tract)
- ) Motor neuron (2-neuron circuit, postgang- and pregang)
- ) Visceral effector
Cholinergic Fibers
Release NT ACh, All ANS preganglionic axons, all parasympathetic postgang axons. 2 types of receptors bind to ACh - Nicotinic & Muscarinic
Adrenergic Fibers
Release NT NE, most sympathetic postganglionic axons (minus sweat glands)
Nicotinic Receptors
Found on sarcolemma of skeletal muscle cells at NMJ.
All postgang- neurons
Hormone-producing cells of adrenal medulla
Effects are always Stimulatory
Muscarinic Receptors
All effector cells stimulated by postgang- cholinergic fibers
Effects can either be inhibitory or stimulatory, depends on receptor type of target organ
Adrenergic Receptors
Major classes: Alpha (1 & 2) and Beta (1,2,3) Effects of NE depend on which subclass on target organ
Atrophine
blocks muscarinic ACh receptors, used to prevent salivation during surgery and dilate pupils
Over-Counter Drugs
Stimulate Alpha-Adrenergic Receptors
Beta-Blockers
Drugs that attach to Beta 2 receptors to dilate lung bronchioles in asthmatics
Sympathetic Tone
(Vasomotor tone) Keeps blood vessels in continual state of partial constriction. Relationship between sympathetic ns and blood pressure, even at rest. Vascular system is innervated by sympathetic fibers
Parasympathetic Tone
Dominates heart, smooth muscle of digestive and urinary tract organs and most glands except sweat and adrenal.