Chapter 14 Flashcards
The development of the nervous system begins with
a thickening of the ectoderm called the neural tube
The brain is protected by
Cranial bones
Cranial menenges
Cerebrospinal fluid
Pia mater
arachnoid mater
dura mater
Blood flows to the brain via
the vertebral and carotid arteries
Blood flows from the brain back to the heart via
the jugular veins
Any interuption in oxygen supply to the brain can result in
weakening, permanent damage, or death of brain cells
The blood brain barrier
protects the brain cells from harmful substances
what is the Neurolemma
The outer nucleated cytoplasmic layerof a schwann cell that completel surrounds the myelin sheath.
What does the neurolemma do
aids in the regrowth and regeneration of an axon
The brain contributes to homeostasis by
receiving sensory input, integrating new and stored information, making decisions, and executing responses through motor activities.
On average, each neuron forms _____ synapses with other neurons.
1000
The brain and spinal cord develop from
the ectodermal neural tube
primary brain vesicles:
prosencephalon, mesencephalon, and rhombencephalon
The prosencephalon (PROS-en-sef′-a-lon), or forebrain, gives rise to ,
the telencephalon and diencephalon
rhombencephalon (ROM-ben-sef′-a-lon), or hindbrain, develops into
the metencephalon and myelencephalon.
the metencephalon and myelencephalon the telencephalon and the diencephalon are the
secondary brain vesicles
The telencephalon (tel′-en-SEF-a-lon; tel- = distant; -encephalon = brain) develops into
the cerebrum and lateral ventricles.
The diencephalon (dī′-en-SEF-a-lon) forms
the thalamus, hypothalamus, epithalamus, and third ventricle.
The mesencephalon (mes′-en-SEF-a-lon; mes- = middle), or midbrain,
gives rise to the midbrain and aqueduct of the midbrain.
The metencephalon (met′-en-SEF-a-lon; met- = after) becomes
the pons, cerebellum, and upper part of the fourth ventricle.
The myelencephalon (mī-el-en-SEF-a-lon; myel- = marrow) forms
the medulla oblongata and lower part of the fourth ventricle.
The adult brain consists of four major parts:
brainstem, cerebellum, diencephalon, and cerebrum
The brainstem is continuous with the spinal cord and consists of
the medulla oblongata, pons, and midbrain
Posterior to the brainstem is the
cerebellum
Superior to the brainstem is the
diencephalon
the diencephalon (di- = through) consists of
the thalamus, hypothalamus, and epithalamus.
Supported on the diencephalon and brainstem is
the cerebrum (se-RĒ-brum = brain), the largest part of the brain.
The four principal parts of the brain are
the brainstem, cerebellum, diencephalon, and cerebrum.
The cranial meninges (me-NIN-jēz)
are continuous with the spinal meninges, have the same basic structure, and bear the same names: the outer dura mater (DOO-ra MĀ-ter), the middle arachnoid mater (a-RAK-noyd), and the inner pia mater (PĒ-a or PĪ-a) (Figure 14.2).
the cranial dura mater has two layers;
the spinal dura mater has only one. The two dural layers are called the periosteal layer (which is external) and the meningeal layer (which is internal).
there is no ___________around the brain.
epidural space
(1) The falx cerebri (FALKS ser-i-BRĒ; falx = sickle)
separates the two hemispheres (sides) of the cerebrum.
The falx cerebelli (ser′-e-BEL-ī)
separates the two hemispheres of the cerebellum.
The tentorium cerebelli (ten-TŌ-rē-um = tent)
separates the cerebrum from the cerebellum.
Cranial bones and cranial meninges
protect the brain.
Blood flows to the brain mainly via
the internal carotid and vertebral arteries
the dural venous sinuses drain into the internal jugular veins to
return blood from the head to the heart
the brain consumes
about 20% of the oxygen and glucose used by the body, even when you are resting.
Because virtually no glucose is stored in the brain,
the supply of glucose also must be continuous
If blood entering the brain has a low level of glucose,
mental confusion, dizziness, convulsions, and loss of consciousness may occur.
The blood–brain barrier (BBB) consists mainly of
tight junctions that seal together the endothelial cells of brain blood capillaries and a thick basement membrane that surrounds the capillaries.
The BBB
allows certain substances in blood to enter brain tissue and prevents passage to others. Lipid-soluble substances (including O2, CO2, steroid hormones, alcohol, barbiturates, nicotine, and caffeine) and water molecules easily cross the BBB by diffusing across the lipid bilayer of endothelial cell plasma membranes
A few water-soluble substances, such as glucose
, quickly cross the BBB by facilitated transport. Other water-soluble substances, such as most ions, are transported across the BBB very slowly.
proteins and most antibiotic drugs—
do not pass at all from the blood into brain tissue. Trauma, certain toxins, and inflammation can cause a breakdown of the BBB.
Cerebrospinal fluid (CSF)
is a clear, colorless liquid composed primarily of water that protects the brain and spinal cord from chemical and physical injuries. It also carries small amounts of oxygen, glucose, and other needed chemicals from the blood to neurons and neuroglia
CSF continuously circulates
through cavities in the brain and spinal cord and around the brain and spinal cord in the subarachnoid space
CSF contains
small amounts of glucose, proteins, lactic acid, urea, cations (Na+, K+, Ca2+, Mg2+), and anions (Cl− and HCO3−); it also contains some white blood cells.
ventricles
four CSF-filled cavities within the brain,
There is one lateral ventricle in
each hemisphere of the cerebrum.
Anteriorly, the lateral ventricles are separated by
a thin membrane, the septum pellucidum
The third ventricle is
a narrow, slitlike cavity along the midline superior to the hypothalamus and between the right and left halves of the thalamus.
The fourth ventricle lies
between the pons and medulla anteriorly and the cerebellum posteriorly.
The CSF has three basic functions in helping to maintain homeostasis.
Mechanical protection
Chemical protection
circulation
Describe the mechanical protection provided by CSF
CSF serves as a shock-absorbing medium that protects the delicate tissues of the brain and spinal cord from jolts that would otherwise cause them to hit the bony walls of the cranial cavity and vertebral canal. The fluid also buoys the brain so that it “floats” in the cranial cavity.
Describe the chemical protection provided by CSF
CSF provides an optimal chemical environment for accurate neuronal signaling. Even slight changes in the ionic composition of CSF within the brain can seriously disrupt production of action potentials and postsynaptic potentials.
describe how the circulation of CSF contributes to homeostasis
CSF is a medium for minor exchange of nutrients and waste products between the blood and adjacent nervous tissue.
Ventricles are
cavities within the brain that are filled with cerebrospinal fluid.
The majority of CSF production is from the
choroid plexuses
choroid plexuses
networks of blood capillaries in the walls of the ventricles
Selected substances (mostly water) from the blood plasma, which are filtered from the capillaries, are secreted by the ependymal cells to produce
the cerebrospinal fluid.
Ependymal cells joined by tight junctions
cover the capillaries of the choroid plexuses.
Because of the tight junctions between ependymal cells,
materials entering CSF from choroid capillaries cannot leak between these cells; instead, they must pass through the ependymal cells.
the blood–cerebrospinal fluid barrier
permits certain substances to enter the CSF but excludes others, protecting the brain and spinal cord from potentially harmful blood-borne substances.
The CSF formed in the choroid plexuses of each lateral ventricle flows into the third ventricle through two narrow, oval openings, the
interventricular foramina
After CSF enters the third ventricle
More CSF is added by the choroid plexus in the roof of the third ventricle. The fluid then flows through the aqueduct of the midbrain (cerebral aqueduct) (AK-we-dukt), which passes through the midbrain, into the fourth ventricle.
CSF enters the subarachnoid space through
three openings in the roof of the fourth ventricle: a single median aperture (AP-er-chur) and paired lateral apertures, one on each side.
After the CSF enters the sub arachnoid space
CSF then circulates in the central canal of the spinal cord and in the subarachnoid space around the surface of the brain and spinal cord.
Normally, CSF is reabsorbed as rapidly as it is formed by the choroid plexuses
Elevated CSF pressure causes a condition called
hydrocephalus
CSF is formed from blood plasma by
ependymal cells that cover the choroid plexuses of the ventricles.
The brainstem is the part of the brain between
the spinal cord and the diencephalon.
The brainstem consists of three structures:
(1) medulla oblongata, (2) pons, and (3) midbrain
medulla oblongata (me-DOOL-la ob′-long-GA-ta), or more simply the medulla,
is continuous with the superior part of the spinal cord; it forms the inferior part of the brainstem (Figure 14.5; see also Figure 14.1). The medulla begins at the foramen magnum and extends to the inferior border of the pons,
bulges on the anterior aspect of the medulla. These protrusions are called the
pyramids
The corticospinal tracts control
voluntary movements of the limbs and trunk
Just superior to the junction of the medulla with the spinal cord, 90% of the axons in the left pyramid cross to the right side, and 90% of the axons in the right pyramid cross to the left side. This crossing is called the
decussation of pyramids
the decussation of pyramids is why
each side of the brain controls voluntary movements on the opposite side of the body.
nuclei
a nucleus is a collection of neuronal cell bodies within the CNS.
The cardiovascular (cv) center
regulates the rate and force of the heartbeat and the diameter of blood vessels
medullary respiratory center adjusts
the basic rhythm of breathing
The vomiting center of the medulla causes
vomiting, the forcible expulsion of the contents of the upper digestive canal through the mouth
The deglutition center (dē-gloo-TISH-un) of the medulla promotes
deglutition (swallowing) of a mass of food that has moved from the oral cavity into the pharynx
Hiccupping is caused by
spasmodic contractions of the diaphragm
Just lateral to each pyramid is an oval-shaped swelling called an
olive
Within the olive is
the inferior olivary nucleus,
the inferior olivary nucleus,
receives input from the cerebral cortex, red nucleus of the midbrain, and spinal cord. Neurons of the inferior olivary nucleus extend their axons into the cerebellum, where they regulate the activity of cerebellar neurons. By influencing cerebellar neuron activity, the inferior olivary nucleus provides instructions that the cerebellum uses to make adjustments to muscle activity as you learn new motor skills.
Nuclei associated with sensations of touch, pressure, vibration, and conscious proprioception are located in the posterior part of the medulla. These nuclei are the
right and left gracile nucleus (GRAS-il = slender) and cuneate nucleus
The gustatory nucleus (GUS-ta-tō′-rē) of the medulla
is part of the gustatory pathway from the tongue to the brain; it receives gustatory input from the taste buds of the tongue
The cochlear nuclei (KOK-lē-ar) of the medulla are part of the
auditory pathway from the inner ear to the brain; they receive auditory input from the cochlea of the inner ear
The vestibular nuclei (ves-TIB-ū-lar) of the medulla and pons
are components of the equilibrium pathway from the inner ear to the brain; they receive sensory information associated with equilibrium from proprioceptors (receptors that provide information regarding body position and movements) in the vestibular apparatus of the inner ear
the medulla contains nuclei associated with the following five pairs of cranial nerves
vestibulocochlear
Glossopharyngeal
Vagus
Accessory XI nerves (cranial portion))
Hypoglossal
Injury to the medulla can be fatal examples of nonfatal medulla injuries include
Symptoms of nonfatal injury to the medulla may include cranial nerve malfunctions on the same side of the body as the injury, paralysis and loss of sensation on the opposite side of the body, and irregularities in breathing or heart rhythm.
The pons (= bridge) lies
directly superior to the medulla and anterior to the cerebellum
the pons is
a bridge that connects parts of the brain with one another
The pons has two major structural components:
a ventral region and a dorsal region
The ventral region of the pons
forms a large synaptic relay station consisting of scattered gray centers called the pontine nuclei
The dorsal region of the pons
contains ascending and descending tracts along with the nuclei of cranial nerves.
Also within the pons is the pontine respiratory group, shown in Figure 23.23. Together with the medullary respiratory center, the pontine respiratory group helps .
control breathing
The pons contains nuclei associated with four pairs of cranial nerves.
Trigeminal
abducens
facial
vestibulocochlear
The midbrain or mesencephalon extends from
the pons to the diencephalon
The aqueduct of the midbrain passes through
the midbrain, connecting the third ventricle above with the fourth ventricle below
The anterior part of the midbrain contains paired bundles of axons known as
the cerebral peduncles
The posterior part of the midbrain,
is called the tectum
the tectum contains four rounded elevations called
superior and inferior colloculi
the superior colliculi
serve as reflex centers for certain visual activities
the inferior colliculi, are
part of the auditory pathway, relaying impulses from the receptors for hearing in the inner ear to the brain. These two nuclei are also reflex centers for the startle reflex, sudden movements of the head, eyes, and trunk that occur when you are surprised by a loud noise such as a gunshot.
The midbrain contains several other nuclei, including the
left and right substantia nigra