Chapter 11 Flashcards
What are the two roles of the testes?
(1) Synthesis of sperm (spermatogenesis) (2) Secretion of male sex hormones into the blood stream
Site of spermatogenesis within the testes
Seminiferous tubules;
Sustentacular cells
Walls of the seminiferous tubules are formed by cellls called sustentacular clues They protect and nurture the developing sperm, both physically and chemically
What are important cells found in the testicular interstitium?
Interstitial cells (also known as Leydig cells); They are responsible for androgen (testosterone) synthesis
Where does the seminiferous tubule empty into?
Epididymis; a long coiled tube located on the posterior of each testicle
Where does the epididymis from each testicle empty?
Into a duct deferens which leads to the urethra
What path does the duct deferens travel to get to the urethra?
It enters the inguinal canal –>joins the duct of the seminal versicle to form the ejaculatory duct –> joins the urethra
Seminal vesicles
A pair of glands located on the posterior surface of the bladder that nourish sperm They secrete about 60 percent of the total volume of the semen into the ejaculatory duct
What are the three glands that produce semen?
The seminal vesicles, the prostrate and the bulbourethral glands Collectively called accessory glands
Prostate gland
Nourishment, allows semen to coagulate after ejaculation
Bulbourethral glands
Lubricate urethra, neutralize acids in the male urethra and female vagina
Erectile tissue
Composed of modified veins and capillaries surrounded by a connective tissue sheath Blood accumulates at high pressures
Three compartments contain erectile tissue
The corpora cavernosa (two of these) and the Corpus spongiosum (one of these)
Three stages of the male sexual act
Arousal, orgasm and resolution
The sexual act events are controlled by an integrating center in the spinal chord, how is it activated/inactivated?
The cerebral cortex can activate this integrating center (in sexual arousal during sleep) or inhibit it (anxiety with sexual function)
What is arousal dependent on?
The parasympathetic nervous input and can be subdivided into two stages: erection and lubrication
Erection
Involves dilation of arteries supplying the erectile tissue. This results in swelling which obstructs venous outflow and causes the erectile tissue to become pressurized with blood
Lubrication
Function of the parasympathetic system. Bulbourethral glands secrete a viscous mucous which serves as a lubricant
What is required for an orgasm?
Stimulation by the sympathetic nervous system which can be divided into two stages: emission and ejaculation
Emission
Propulsion of semen into the urethra by contraction of smooth muscles
Ejaculation
Semen is propelled out of the urethra by rhythmic contractions of muscles surrounding the base of the penis
Resolution (2-3 minutes)
Or “returning to normal”, unstimulated state, is also controlled by the sympathetic nervous system Caused by a constriction of erectile arteries which results in decreased blood flow to the erectile tissue and allows veins to carry away trapped blood
Gametogenesis
Process by which diploid germ cells undergo meiotic division to produce haploid gametes
Syngamy
Fusion of sperm with the egg. The gametes produced by males and females differ dramatically in structure but contribute equally to the genome of the zygote
Spermatogenesis
Sperm synthesis. It begins at puberty and occurs in the testes throughout adult life
What is the site of spermatogenesis?
In the seminiferous tubule Spermatogenesis occurs with the aid of the specialized sustentacular cells found in the walls of the seminiferous tubule
Where are immature sperm precursors found?
The outer wall of the tubule
Where are nearly-mature spermatozoa’s deposited?
In the lumen and the they are transported into the epididymis
Germ cells
Give rise to male and female spermagonia Can germinate and give rise to full organisms
Spermatogonium Job
(1) Mitotically reproduce prior to meiosis (2) Replicate DNA in S phase of meiosis “SpermatoGONium is GONNA become a sperm”
Primary spermatocyte job
Meiosis I “Any gamete precursor (male or female) with “cyte” undergoes a meiotic division”
Secondary spermatocyte job
Meiosis II “The secondary spermatoCYTE undergoes the second meiotic division”
Spermatic Job
Turn into a spermatozoan “The spermatid’s a kid, almost mature”
Spermatozoan Job
Finish maturing: (1) in seminiferous tubule (2) in epididymis “Just remember that a mature sperm is called a spermatozoan”
Where do the final stages of sperm maturation occur?
In the epididymis
Where do spermatids develop?
Spermatids develop into spermatozoa in the seminiferous tubules with the aid of sustentacular cells
Acrosome
Contains lytic enzymes needed for penetration of the ovums protective layers
Bindin
Protein that allows for attachment to receptors on the zone pecullia surrounding the ovum
Process by which spermatids develop into spermatozoa?
(1) DNA condenses and cytoplasm shrinks to from a head (contains haploid nucleus) (2) Flagellum forms tail (3) Neck region carries mitochondria
Testosterone
Plays the essential role of stimulating division of spermatogonia
Luteinizing hormone (LH)
Stimulates the interstitial cells to secrete testosterone Secreted by anterior pituitary gland and uses systematic circulation to reach its target
Follicle stimulating hormone (FSH)
Stimulates the sustenacular cells which support and nourish sperm in seminiferous tube
Inhibin
Is secreted by sustenacular cells; its role is to inhibit FSH release
Wolffian ducts
Can develop into male internal genitalia (epididymis, seminal vesicles, and ductus deferens) Can develop into either genitalia
Müllerian ducts
That can develop into female internal genitalia (uterine tubes, uterus and vagina) Müllerian ducts are the default
Although external genitalia is also default, it is not
Derived from the Müllerian ducts
Genetic information on Y chromosomes leads to the development of
Testes, which cause male internal and external genitalia to develop by producing testosterone and Müllerian inhibiting factor (MIF)
Müllerian inhibiting factor (MIF)
Causes regression of Müllerian ducts
Dihydrotesterone
Testosterone enters the systemic circulation and is converted into dihydrotestosterone in target tissues in order to exert its effects.
Three main fetal precursors of the reproductive organs are
Wolffian ducts, Müllerian ducts and the gonads Structures arising from these ducts tend to have the same function
Analogous structures
Wolffian ducts and Müllerian ducts arise from different precursors
Homologous structures
Derived from the same underdeveloped structure i.e. Gonads
Androgens
All hormones involved in the development and maintenance of male characteristics
Estrogens
All hormones involved in development and maintenance of female characteristics
What happens to testosterone after birth
levels of testosterone fall to negligible levels until puberty, at which time increases and remains high for the remainder of adult life
Secondary sexual characteristics
Maturation of the geneticist,male distribution of facial and body hair, deepening of the voice and increased muscle mass. Pubertal growth spurt and fusion of the epiphyseal also results
Why is estrogen required at the beginning of puberty?
Required to regulate the uterine cycle and for the development and maintenance of female secondary sexual characteristics Maturation of the genitalia, breast development, wider hips and public hair
Gonadotropin releasing hormone (GnRH)
From the hypothalamus stimulates the pituitary to release the gonadotropins. Stimulates release of FSH and LH
What is the role of FSH and LH in females
FSH stimulates the granulosa cells to secrete estrogen and LH stimulates the formation of the corpus luteum and progesterone secretion