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7th > Chapter 106- Aging > Flashcards

Chapter 106- Aging Flashcards

1
Q

Unavoidable physiologic changes in the skin influenced by genetic and hormonal factors

A

Intrinsic or chronologic skin aging

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2
Q

Most powerful source of extrinsic skin aging

A

UV radiation

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3
Q

Larger contributor of skin aging due to greater depth of penetration

A

UVA

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4
Q

Decreased epidermal turnover rate by __ during 3rd to 8th decades

A

30-50%

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5
Q

By 60 years old, nearly __% have graying of hair

A

50

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6
Q

Decrease in sebaceous gland number is noted during aging.

True or False

A

False, constant in no

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7
Q

Dry, extremely pruritic fissured skin with scales

A

Asteatotic eczema

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8
Q

Common complaint of elderly

A

Pruritus or itchy skin

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9
Q

Blood resorption of senile purpura is noted within __ weeks

A

2

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10
Q

Senile purpura is associated with use of

A

Aspirin

Anticoagulants

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11
Q

Preventable changes due to environmental factors

A

Photoaging

Extrinsic Aging

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12
Q

Elderly is defined as

A

X> 65 years old

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13
Q

Intrinsic vs extrinsic

  1. Loss of rete ridges
  2. Reduced ECM
  3. Reduced fibroblasts
  4. Reduced collagen, elastin
  5. Reduced lipids
  6. Solar elastosis
  7. Epidermal thinning
A

2.3.6. Extrinsic

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14
Q

Intrinsic vs Extrinsic

  1. Xerosis
  2. Fine wrinkles
  3. Telangiectasia
  4. Dyspigmentation
  5. Pallor
  6. Decreased elasticity
  7. Fragility
A

1, 6, 7 - both
2, 5, intrinsic
3, 4 extrinsic

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15
Q

Normal consequence of aerobic metabolism

A

Production of ROS

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16
Q

Tandem DNA sequence that are shortened with each somatic cell division

17
Q

Final pathway for both intrinsic aging and photoaging

A

Disruption of normal loop at end of telomeres

18
Q

Cell cycle is irreversibly arrested

A

Replicative senescence

19
Q

Of the UV radiation that reaches the earth’s surface, __% is UVA and __% is UvB

20
Q

Source of direct DNA damage, inflammation, and immunosuppression

21
Q

50% of the total solar spectrum which generated ROS

A

Visible light

22
Q

__ does not penetrate thte skin

A 
Infrared B (1400 - 3000nm)
Infrared C (3000nm - 1mm)
23
Q

Critical modulator of redox balance and oxidative stress

A

Estrogen receptor signaling (genomic and nongenomic)

24
Q

Postmenopausal changes (5)

A 
Dryness
Thinner skin
Reduced elasticity
Increased wrinkles 
Decreased collagen content
25
Layer of epidermis most greatly impacted by epidermal atrophy
Spinous cell layer
26
Most pronounced and consistent histologic changes of aged skin (2)
Flattening of DEJ | Loss of rete ridges
27
Average thickness of stratum corneum changes with age. | True or False
False, does not
28
Between 50 and 80 years old, __ results in impaired lipid processing enzymatic activity
Abnormal stratum corneum acidification
29
Decrease in epidermal __ accounts for increased dryness and scaling of skin
Filaggrin
30
Number of functional melanocytes decline by __% per decade
20
31
Most striking histologic alteration of photodamaged dermis
Solar elastosis
32
__ is independent of UV exposure and is likely a result of focal epidermal homeostasis
Seborrheic keratoses
33
___ has been implicated in seborrheic keratoses
Endothelin 1
34
Small, circular, oval red papules due to proliferation of blood vessels that increase in size and number with age and bleeds with minor trauma
Senile angioma | Cherry angioma
35
SCC and AK are associated with habitual sun exposure. | True or False
True
36
BCC and melanoma are associated with history of __ sun exposure
Habitual and intense intermittent
37
Cancer of the inner lining of blood vessels commonly present on head and neck
Angiosarcoma
38
Angiosarcoma expresses high levels of __
VEGF | VEGFR2
39
Defining characteristic of polycythemia vera
Pruritus

7th (23 decks)

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