Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

7th > Chapter 105 - Skin Changes and Disease in Pregnancy > Flashcards

Chapter 105 - Skin Changes and Disease in Pregnancy Flashcards

1
Q

Chnages most commonly observed in pregnancy

A

Pigmentary disturbances

  • hyperpigmentation
  • linea nigra
  • melasma
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Irregular blotchy facial hyperpigmentation that occurs in 70% of pregnant women

A

Melasma or chloasma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Melasma is aggravated by: (2)

A

Sun exposure

OCP intake

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Significant change in nevi size is a feature of most pregnancies.
True or False

A

False, not

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The most common structural change in pregnancy

A

Striae gravidarum
Striae distensae
Stretch marks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Strongest risk factors for development of striae: (3)

A

Family history
Personal history
Race

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Most common vascular lesion to develop

A

Spider angiomata

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Dermatoses associated with fetal risk (3)

A

Pemphigoid gestationis
Intrahepatic cholestasis of pregnancy
Pustular psoriasis of pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Immunologically mediated, intensely prurituc vesiculobullous eruption of mid to late pregnancy associated with fetal risk

A

Pemphigoid gestationis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Reversible form of cholestasis in kate pregnancy associated with biochemical abnormalities but remits within 2 to 4 weeks of delivery

A

Intrahepatic cholestasis of pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Rare, acute pustular eruption accompanied by fever leukocytosis and elevated ESR

A

Pustular psoriasis of pregnancy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Physiologic nail findings during pregnancy (5)

A 
Subungual hyperkeratosis
Distal onycholysis
Transverse grooving
Brittleness
Accelerated growth
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Increase or decrease in pregnancy

  1. Eccrine function
  2. Sebaceous function
  3. Apocrine function
A
  1. Increased (except palms)
  2. Increased
  3. Decreased
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Bluish discoloration of vagina and cervix

A

Jacquemier Chadwick sign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Cervical softening

A

Goodell sign

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Pemphigoid gestationis is associated with: (2)

A

Increased small for gestational age births

Premature delivery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

In PG, DIF shows (pathognomonic)

A

(+) linear band C3 with or without IgG at DEJ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Gold standard for diagnosis of PG

A

DIF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

96% specific for PG

A

ELISA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Risk of fetal complications of PG correlates with maternal disease severity
True or False

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

__% of women with PG flares postpartum and will require treatment; with OCP intake or during menstruation

A

75

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Treatment for pemphigoid gestationis (4)

A

Topical steroids
First gen antihistamines
Plasmapheresis
IVIg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

PG can also occur in abnormal pregnancies (3) implicating a role for paternally derived tissues

A

Hydatidiform mole

Choriocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Intraheptic cholestasis of pregnancy, rare, reversible, occurs in late pregnancy when serum concentrations of ___ reach their peak

A

Estrogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Second only to viral hepatitis in causing jaundice in pregnant women
ICP
26
ICP is most common in
Scandinavia | South America
27
Only pregnancy dermatosis that presents without primary skin lesions
Intrahepatic cholestasis of pregnancy
28
Patients with ICP may complain of nocturnal pruritus only. | True or False
True
29
Pruritus precedes onset of jaundice by 1-4 weeks | True or False
True
30
Harmful effects of fetus by intrahepatic cholestasis of pregnancy include (3)
Increase in premature births Intrapartum fetal distress Fetal death
31
Recurrence of ICP in ___% of subsequent pregnancies
45 to 70%
32
Genes muted in ICP include (3)
ABCB4 ABCB11 ATP8B1
33
Single most sensitive indicator of ICP
Elevation in serum bile acids
34
Common features of ICP 1. Serum total bile acid concentrations greater than ___ 2. Cholic acid to chenodeoxycholic acid ratio greater than ____ or cholic acid proportion of total bile acids greater than ___% 3. Glycine conjugates to taurine conjugates of bile acids ratio less than ___ or glycocholic acid concentration greater than __
1. 11 uM (4.6 to 8.7 uM) 2. 1.5 (0.7 to 1.5); 42% 3. 1 (0.9 to 1.2); 2uM (0.6 to 1.5uM)
35
Elevation in this liver enzyme is sensitive for ICP but is not seen in heathy pregnancies
ALT
36
Increased or decreased in ICP 1. Gamma glutamyl transferase 2. Direct fractions of bulirubin 3. Alpha 2 globulin 4. Beta globulin 5. Albumin
All are increased except for 5.
37
Routine liver tests alone are sufficient for diagnosis of ICP True or False
False, not
38
Cutaneous biopsy aids in diagnosis of ICP | True or False
False, does not
39
Hallmark of ICP
Symptoms and biochemical abnormalities resolve in 2-4 weeks of delivery
40
Complications in fetus of patients with ICP are correlated to
Higher bile acid levels Increase placental anoxia Increase incidence of meconium stained amniotic fluid
41
Essential to the management of ICP
Intense fetal monitoring
42
Current treatment of choice for ICP
Ursodeoxycholic acid 450 mg to 1200 mg | For mild cases, bland emollients and topical anti pruritic
43
Most recommend early induction of labor at __ wks of gestation or earlier for patients with ICP
38
44
Originates in flexural areas spreading centrifugally with onycholysis sparing face, palms, and soles.
Pustular psoriasis of pregnancy
45
Life threatening maternal complications of pemphigoid gestationis may result from (2)
Profound hypocalcemia and bacterial sepsis
46
The most feared complications of pustular psoriasis of pregnancy
Placental insufficiency | Stillbirth or neonatal death
47
How to distinguish pustular psoriasis of pregnancy from generalized pustular psoriasis
Absence of positive family history Abrupt resolution of drug delivery Recur only during subsequent pregnancies Factors known to trigger psoriasis are absent
48
Common lab derangements include
``` Leukocytosis Neutrophilia Elevated ESR Hypoferric anemia Hypoalbuminemia Decreased Ca, Phosphate, Vitamin D ```
49
Cardinal feature of pustular psoriasis of pregnancy
Rapid resolution of symptoms after delivery
50
Recurrences of Pustular psoriasis of pregnancy are common in subsequent pregnancies and more severe with earlier onset in gestation. True or False
True
51
First line therapy for pustular psoriasis of pregnancy
Cyclosporine 5-10mkday | Infliximab TNF alpha blocking agent
52
Earlies sign of fetal hypoxemia
Fetal decelerations
53
Dermatoses not associated with fetal risk in pregnancy
PUPPP | Atopic eruption of pregnancy
54
Common self-limited intensely pruritic dermatoses that occurs almost exclusively in primigravidas during late pregnancy
Polymorphic eruption of pregnancy
55
Papules surrounded by pale halo coalesce to form erythematous plaques that starts within the striae gravidarum, spread to involve buttocks and thighs, sparing the umbilicus
Polymorphic eruption of pregnancy
56
Rule for polymorphous eruption of pregnancy
Spontaneous remission within days of delivery
57
Management of polymorphous eruption of pregnancy
Topical corticosteroids | Oral antihistamines
58
DIF/ IDIF studies of polymorphous eruption of pregnancy
DIF: granular or absent C3, IgM, or IgA deposits at DEJ or around blood vessels IDIF: negative
59
Benign pruritic condition of pregnancy characterized by eczematous and/or papular eruption in individuals with a personal and/or familial atopic background and/or serum IgE levels
Atopic eruption of pregnancy
60
Most common pruritic disorder in pregnancy
AEP (50%)
61
Presents earlier than other pregnancy associated dermatoses
AEP
62
Classic eczematous eruption affecting flexural surfaces and the face occurs in 2/3 of individuals
AEP E type
63
Discrete pruritic excoriated papules with a predilection for extensor surfaces, with truncal involvement less common
AEP P type
64
AEP, preferential expression of ___ cytokines
TH2
65
In a mother with AEP, there will be increased risk of AD for the infant. True or False
True, for mothers with known history of atopy
66
Management for AEP
Midpotency topical corticosteroids | Antihistamines
67
Helpful for truncal, follicular lesions of AEP
BPO
68
In severe cases of AEP, ___can be used
UVB phototherapy
69
Duration of symptoms of polymorphic eruption in pregnancy averages
6 weeks
70
Involvement of palms. soles, or skin above the breasts is exceptional in PUPPP. True or False
True
71
Linea nigra is irreversible | True or False
False, reversible
72
Physiologic hair changes (4)
Hirsutism | Telogen effluvium
73
Treatment for PG
Topical steroids and/or systemic antihistamines
74
___ of ICP patients may progress to jaundice, pale stools, dark urine
1 in 5
75
PUPPP is associated with
Multiple gestation
76
Total serum IgE is elevated in __ patients of AEP
20-70%

7th (23 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions