Chapter 10- Blood and Circulatory Flashcards
Blood
Transports O2 and nutrients to all tissues. Remove waste products of cellular metabolism. Help with body defenses/immune system. Maintain body homeostasis
Pulmonary circulation
Provides exchange of O2 and CO2 in the lungs
Systemic circulation
Provides for nutrient exchange and wastes between the blood and the cells throughout the body
Arteries
Transport blood away from the heart into the lungs or to body tissues
Arterioles
Smaller branches of the arteries that control the amount of blood flowing into the capillaries
Capillaries
Very small vessels and forms microcirculation
Three layers
Tunica intima, tunica media, tunica adventia
Autoregulation
Controls localized vasodilation and vasoconstriction
Components of blood
Water and solutes, cells, formed liquid elements, erythrocytes, leukocytes, thrombocytes, or platelets
Hematocrit
Proportion of the cells shows the viscosity of the blood
Plasma
Clear yellowish fluid remaining after cells have been removed
Serum
Fluid and solutes remaining after the cells and fibrinogen have been removed from the plasma. Plasma proteins include albumin which maintains osmotic pressure in the blood, globulins or antibodies, and fibrinogen which is essential for formation of blood clots
Hematopoiesis
Production of blood cells from red bone marrow
Dyscrasia
Blood disorders involving cellular components of the blood
Erythrocytes
RBC. Flexible discs and contain hemoglobin
Erythropoietin
Hormone from the kidney that stimulates erythrocyte production in the red bone marrow in response to tissue hypoxia
Hemoglobin
Becomes fully saturated with oxygen in normal lung function and respiration
Oxyhemoglobin
Bright red color; arterial blood
Depxyhemoglobin
Reduced hemoglobin; dark and bluish red in color; found in venous blood
Bicarbonate ion
Form of carbon dioxide when it is transported in blood
Hemostasis
Process to stop bleeding
Platelets
Non-nuclear fragments of megakaryocytes
First step of hemostasis
Vasoconstriction of vascular spasm. In small blood vessels decreases blood flow and may get platelet plug to form
Second step of hemostasis
Thrombocytes stick to underlying tissue at injury site and if blood vessel is small can form a platelet plug in the vessel
Third step of hemostasis
Requires larger vessels; clotting factors in inactive forms in circulating blood are activated
Blood clotting
Damage tissue and platelets release factors that start a series of sections involving a series of reactions involving numerous clotting factors. Produces prothrombin activator. A fibrin mesh forms to trap cells, making up a solid clot or thrombus, and stopping the flow of blood. The clot gradually shrinks or retracts, pulling the edges of damaged tissue closer together and sealing the site. Circulating factors are mainly produced in the liver. Vitamin K, a fat-soluble vitamin, is required for most clotting factors. Applying pressure and cold to the area reduced blood flow. Also, thrombin topically helps
Prothrombin or factor II
Converted to fibrin threads through the action of the thrombin
Fibrinogen or factor I
Converted into fibrin threads through the action of thrombin
Fibrinolysis
Breakdown of the fibrin in blood clots
Heparin
Can be given by IV or subcutaneously. Does not dissolve clots, but keeps new ones from forming
tPA and Streptokinase
Clot busters. Help with heart attacks and strokes
Blood types
Determined by the presence of certain antigens on the cell membranes of that person’s erythrocytes
Blood transfusion
Always carefully checked between donor and recipient
Universal donors
Type O blood; lack A and B antigens
Universal recipients
Type AB blood
Transfusion reaction
Feeling of warmth in the vein, flushed face, headache fever, chills, pain in chest and abdomen, decreased BP and rapid pulse
Rh factor
May cause blood incompatibility if the mother is Rh-negative and the fetus is Rh-positive
CBC
Includes WBC, RBC, platelet count, hemoglobin, and hematocrit
Hematocrit
Percentage of blood volume composed of RBC’s and indicates fluid and cell content
Hemoglobin
The oxygen-carrying capacity of the blood
Whole blood, packed RBC, packed platelets
Given for severe anemia or thrombocytopenia
Plasma or colloidal volume-expanding solutions
Given without risk of reaction because lacks antigens or antibodies
Artificial blood products
Compatible with all blood types but will not support immune function or clot
Epoetin alfa
Form of erythropoietin. Can be given by injection to stimulate the production of RBC before certain procedures such as hip replacement
Bone marrow or stem cell transplants
Treat some cancers, severe immune deficiency, or severe blood cell diseases
Hemophilia
Lack of blood clotting capability
NoVo seven
Used for hemophiliacs. Can also be used to treat combat trauma