Chapter 1: Homeostasis Flashcards
Physiology
Study of how organisms function
Cells
The smallest structural unit that can perform all the functions needed for life
Cell Differentiation
The process to becoming specialized for a task
4 Categories of Cells
Muscle, Neuron, Epithelial, Connective
What cell type are blood vessels considered?
Connective Cells
Tissue
Group of similarity differentiated cells
Organ
Collection of tissues that work together for the same function
Organ System
Collection of organs that work together for a common function
Muscle Cell Function
Transmit force
Muscle Cell Types
Skeletal, Cardiac, and Smooth
Neuron Cell Function
To initiate, integrate, and conduct electrical signals
Basement Membrane
Thin layer of ECM that the epithelial cells sit on
Basolateral Side
Faces the basement membrane
Apical Side
Faces the lumen
Tight Junctions
Fill the space between epithelial cells and have selectively permeable membranes
Loose connective tissue
loose tissue below the epithelial layer
Dense connective tissue
Tendon, Ligament, Bone, Adipose
Fluid connective tissue
Blood
ECM [ two functions ]
Provides a stable scaffold, transmits chemical messengers cell to cell
Ropelike ___ fibers, and rubber band like ____ fibers.
Collagen, and elastin
Functional Unit
Smallest unit with a common function
Intracellular Fluid
Inside cells, 67% of body fluid
Extracellular Fluid
Fluid surrounding cells and in blood 20%
Interstitial Fluid
surrounds cells, but not counting the blood plasma
Comparing concentrations between blood plasma and interstitial fluid
about the same
5 common physiological variables
blood pressure, body temp, oxygen, glucose, sodium ions
Homeostasis
Relatively stable internal conditions
Dynamic constancy
Variable may fluctuate in short term, but be averagely stable or predictable in the long term
Pathophysiology
A condition giving loss to homeostasis
Steady state vs. equilibrium
Both have a constant variable, but equilibrium does not require additional energy to maintain this
Negative Feedback System
A system result will reduce the conditions that made it start in the first place
How is the production of ATP an example of negative feedback?
As energy is stored in ATP bonds, it slows the enzymes that break down glucose, therefore preventing additional creation of ATP.
Example of positive feedback:
Giving birth. Uterine contractions cause release of oxytocin, which further causes more uterine contractions.
Set point
The value at steady state for a particular biological variable
Clashing demands
Sometimes it is only possible to maintain a set point at the expense of less important set points
Why is it a benefit that multiple systems can control a single parameter?
The redundancy allows for the parameter to continue to be regulated in case a disease knocks out one of the systems.
Feedforward example
When sensors can sense the body external temperature to proactively start the body warming before it actually starts to cool internally.
Reflex
Involuntary built in response to a specific stimulus
Reflex Arc Components
Stimulus–>Receptor–>Integrating Center–>Effector–>Response
Afferent and Efferent Pathways
Afferent: Sensing the stimulus up to the integrating center
Efferent: From the integrating center to the effector
Hormone
Chemical messenger sent normally through blood to another site
Local Homeostatic Responses
Response in a local area to a stimulus
Neurotransmitters
Transmitted between neurons or to their effectors
Paracrine
Transmission within a local neighboring area
Autocrine
Signaling of a cell to itself
Juxtacrine
Signaling of a cell to another when touching through the membrane
Diffusion
Random thermal motion of a molecule
Flux Gradient (In General)
Solute particles move from high to low concentration
Define “Net flux”
While flux may occur in both directions, net flux is the summation of both directions.
Lipid Bilayer is made of:
Phospholipids… with a polar phosphate head group, and a non polar fatty acid chain.
What sort of substances can get through the bilayer?
Small non polar molecules, such as O2, CO2, ethanol, fatty acids, steroid hormones
What sort of substances cannot get through the bilayer without help?
Large polar molecules such as glucose, or charged ions [Na+,K+,Cl-,Ca2+]
What elements of ion channels make them selective?
Size of the pores, and the charge of the channel.
What are three ways that channels can be gated?
Chemical, Electrical, Mechanical
Define a ligand:
A chemical messenger
In what way is a plasma membrane generally charged?
Positive on the inside, and negative on the outside
What are the three general types of Mediated Transport?
1) Facilitated Diffusion
2) Primary Active Transport
3) Secondary Active Transport
Describe 4 properties of facilitated diffusion:
1) Net flux is down the gradient
2) No energy required
3) Selectivity because of binding sites
4) Transporter can be at saturation due to limited amount of binding sites.
What is a primary example of Facilitated Diffusion?
Glucose transport into the body of the cell
What is the primary example of the Primary Active Transport?
Na+K+ATPase Pump
Before Primary Active Transport, what is the general concentration of K+ and Na+
Intracellular: Low Na+, High K+
Extracellular: High Na+, Low K+
PAT step 1:
3 Na+ ions, and ATP attach to the binding sites
PAT step 2:
ATP –> ADP, and the channel is opened, and the Na+ goes out of the cell
PAT step 3:
2K+ attach to binding sites from outside of the cell, and phosphate is removed, switching the conformation of the channel back to open into the cell, releasing the 2K+
Describe 4 properties of Active Transport
1) Flux is against the concentration gradient
2) Energy required
3) Certain selectivity due to binding sites
4) Channel can be saturated due to limited binding sites
Intracellular Ion Concentrations
Na+ 15mM, K+ 150mM
Extracellular Ion Concentrations
Na+ 145mM, K+ 5mM
Describe 4 properties of Secondary Active Transport
1) Against a concentration gradient
2) Energy provided by an ion’s gradient
3) Certain Selectivity
4) Transporter saturation
What is the usual ion in Secondary Active Transport?
Na+
What does it mean for a mediated transport system to saturate?
Since there is a limited amount of channels and binding sites, there is a maximum amount of solute particles that can cross the membrane at a time.
Channels in the membrane for water:
aquaporins
Can water pass through the lipid bilayer?
Yes because the molecules are small, but they are also polar, and therefore quite slow for any efficient physiological process.
Osmolarity
The total solute concentration of a solution
Osmole
one mol of solute particles
What is the osmolarity of 1 mol of NaCl in 1 liter of water?
2 osmoles/liter
What is the general osmolarity of the ECF?
300mOsm
What is tonicity?
The concentration of non - penetrating solute
What happens to a cell in a hypotonic solution?
The water concentration outside of the cell is greater than inside the cell, therefore water will enter the cell, causing it to expand.
What happens to a cell in an isotonic solution?
Nothing. It will retain its volume.
What happens to a cell in a hypertonic solution?
The water concentration inside the cell is greater than outside the cell, therefore water will leave the cell, causing it to shrink.
Endo and Exo cytosis
When a lipid bilayer is formed around particles that fuse to the membrane either allowing for entrance [endo] or exiting [exo] of solute particles.
Functional unit in the Nervous System
nerve cell or neuron
Nerve
collection of nerves bound together by connective tissue
CNS: Central Nervous System
Brain and spinal cord
PNS: Afferent division defintion
sensory cells that send signals AT or TOWARDS the CNS
PNS: Efferent division definition
cells that send signals AWAY from the CNS to the periphery
Somatic sensory
touch
Visceral sensory
organs
Special sensory
hear, taste, smell, see
Somatic motor
skeletal muscle
Autonomic motor: enteric
gi tract
Autonomic motor: sympathetic
fight or flight
Autonomic motor: parasympathetic
rest and digest
Dendrites
incoming receiving branches of neuron
Cell body of nerve is also called:
soma
Initial segment of nerve cell is also called [2]:
axon hillock, trigger zone; is where the e- starts
Axon
Sends signal from soma to axon terminals