CHAPTER 09: TRUNK Flashcards
What is gynaecomastia?
Abnormal breast development in ♂, increase in ductal tissue and stroma.
What is the pathophysiology?
↑ oestrogen, ↓ androgen, or deficit in androgen receptors.
↑ oestrogen : testosterone ratio leading to unopposed oestrogen
What is the aetiology?
Idiopathic - majority
Physiological
- Neonatal (maternal oestrogens)
- Pubertal (andogen - oestrogen imbalance) 75% resolve
- Senile (peripheral fat conversion of testosterone -> oestrogen by aromatase, testicular failure, inc fat levels)
Pathological
Congenital - Hypogonadism o Pituitary ↓ GRH (=LH) o Androgen insensitivity syndrome (5α reductase deficiency) o Klinefelter’s (XXY) 20-60x ↑ breast ca risk o Congenital anorchism - Hyperoestrogenic o True hermaphrodite o Congenital adrenal hyperplasia o ↑ peripheral aromatase
Acquired
- metabolic
- liver cirrhosis
- testicular tumours (seminoma, teratoma, choriocarcinoma - BhCG, Leydig, Sertoli cells - oestrogen.
- adrenal & pituitary, hypothalamus tumours
- breast cancer
- lung ca
- renal disease
Pharmacological
- recreational drugs - marijuana, anabolic steroids
- spironolactone, digoxin, TCA
- prostate ca Rx - Zoladex (LHRH analogue), antiandrogens (cyproterone acetate), oestrogens (stilboestrol)
What is the classification of gynaecomastia?
Simons Classification - PRS 1973
Grade I = small (or subareolar button)
- excise
Grade IIa = moderate enlargement with no skin excess
- lipo +/- excise
Grade IIb = moderate enlargement with extra skin
- excise +/- liposuction
Grade III = marked enlargement with extra skin
- BBR or horizontal ellipse excision
Other classifications
Rohrich 2003
Cordova JPRAS 2008
What is the histological classification of gynaecomastia?
- Florid pattern - highly cellular fibroblastic stroma, increased budding ducts (1st 4mths)
- Intermediate type
- Fibrous type - extensive stromal fibrosis, minimal ductal proliferation (after 12mths)
Gynaecomastia - history and examination
History
- age of onset, rate of growth
- psychological effects
- symptoms: pain, nipple discharge
- PMH, THx, FHx, SHx recreational drugs
Examination
- chest wall, pectus, scoliosis, skin quality, symmetry, testicular, abdominal, thyroid
What medical treatments are there?
Tamoxifen (reduce pain)
Danazol (60% intermediate response rate)
Clomiphene (in proliferative phase)
usu not very effective
What tests may be indicated?
Breast pathology - triple assessment
Testicular cancer - Testosterone, oestrogen, α-FP, β-HCG, PSA, hGH
Intracranial pathology - prolactin, FSH, LH
Hepatic abnormality - LFT
Biochemistry - prolactin, LFT, testosterone, oestrogen, LH, FSH, TFT, U&E
α-FP, β-HCG, γ-GT, PSA, hGH
Mammography
What is the aim of treatment?
restoration of normal chest contour
minimising scars
protecting NAC
What are the principles of gynaecomastia surgery
- may avoid scars in younger pts, liposuction & disc excision 1st stage
- allow skin to settle +/- skin excision 2nd stage
- liposuction makes excision easier
What are the surgical options?
Liposuction
Open excision
Skin resection
What types of incisions are there?
Inferior Periareolar (Webster 46)
Circumareolar (Davidson 79, Smoot 98, Saad & Kay, Ann.R.Coll.Surg.Eng 1984)
Transverse or hemi transverse = through nipple
PERS incision - horizontal skin ellipse, with NAC vertical bipedicle leaving transverse scar
Inframammary
Wise Pattern or Vertical Scar
What is the surgical treatment for gynaecomastia?
Consider skin excision and fat / glandular excision separately (like breast reduction)
Grade 1
Liposuction
circumareolar incision and excise disc of breast tissue (button)
Grade 2
A - liposuction and circumareolar incision to excise button
B - skin: donut mastopexy, beveled excision of breast disc and liposuction to feather edges
Grade 3
Breast reduction
- inferior pedicle markings
- skin : circumareolar + subcutaneous mastectomy
- MWL : free nipple grafting
- horizontal skin ellipse and NAC vertical bipedicle, leaving transverse scar (Pers)
What are the complications?
Complications
- High comp rates with open (Courtiss 87, Steele 02)
Early
Haematoma
Infection
Late Asymmetry Hypertrophic scarring Altered nipple sensation Saucer deformity Inadequate correction of gland volume or skin excess Nipple stuck to chest wall
TUBEROUS BREAST AND POLANDS SYNDROME
SEE AESTHETIC BREAST
Describe the embryology and anatomy of the chest wall
development of ribs, costal cartilages and sternum begins at week 6
ribs 1-7 fuse with sternum wk 9
Inspiratory muscles → SCM, scalenes
Expiratory muscles → Rectus abdo, Ext. Oblique, Int. Oblique.
Flail segment = >4 rib fractures or >5cm segment