Ch4 BB AALA Flashcards
1
Q
- What of the following activities are attributable to acetylsalicylic acid?
a. analgesic
b. antipyretic
c. anti-inflammatory
d. neither of them
e. all of them
A
d?
2
Q
- True or False: Prostaglandin production is inhibited by aspirin.
A
True
3
Q
- True or False: Anxiolytics are drugs used to treat the consequences of pain.
A
True
4
Q
- True or False: Meperidine is 10 times more effective analgesic than morphine.
A
False
5
Q
- What type of stimli have been used in analgesiometry assays:
A
heat and cold
pressure and organ distension
incision and irritating chemical
6
Q
- True or False: When administered following a surgery, opioids may have effects on activity, reactivity and feeding behaviors in animals.
A
True
7
Q
- Prostaglandins that are released following tissue damage can increase the sensitivity of nociceptors to:
A
other chemicals
mechanical stimuli
thermal stimuli
8
Q
- True or False: Some analgesic, antipyretic and anti-inflammatory drugs regulate neutrophil phagocytosis and secretion of beta-glucorinase and acid protease.
A
True
9
Q
- Which of the following NSAID are considered nonacidic:
a. celecoxib
b. meloxicam
c. carprofen
d. aspirin
A
a
10
Q
- True or False: Nonacidic NSAID lack anti-inflammatory activity.
A
True
11
Q
- True or False: Antipyretic activity of NSAID is due to the prevention of PGE2 production in the hypothalamus.
A
True
12
Q
- True or False: Gastric ulceration may be a side effect caused by the local irritant effect of an orally administered NSAID.
A
True
13
Q
- True or False: Prostaglandins promote acid secretion by the stomach.
A
False
14
Q
- True or False: Prostaglandins promote the secretion of cytoprotective mucus in the intestine.
A
15
Q
- True or False: NSAID promote synthesis of thromboxane A2 in platelets.
A
False
16
Q
- True or False: Inhibition of prostaglandin synthesis prevents colon carcinogenesis.
A
True
17
Q
- True or False: Norepinephrine and angiotensine II induce vasoconstriction of renal glomeruli.
A
True
18
Q
- True or False: Prostaglandins induce vasodilatation.
A
True
19
Q
- What are some situations a patient shouldn’t be treated with a NSAID?
A
congestive heart disease
ascites
hypovolemia
chronic renal disease
20
Q
- Which of the following drugs are not salicylates:
a. aspirin
b. diflunisal
c. carprofen
d. meloxicam
e. c and d
A
e
21
Q
- What are major side effects are attributable to salicylates:
A
stimulate respiration
GI hemorrhage
Hepatotoxicity
Prolongation of bleeding time
22
Q
- True or False: Salicylates orally administered are absorbed rapidly mainly by the stomach.
A
False
23
Q
- What are 4 important aspects of distribution of salycilates:
a. is a pH dependent passive process
b. crosses the placenta
c. transported into the CSF
d. 80-90% is bound to albumin.
A
pH dependent passive process
crosses the placenta
transported into the CSF
80-90% is bound to albumin.
24
Q
- What are 3 important aspects of excretion of salicylates:
A
excreted in urine
high clearance rate in some species due to acidic urine
plasma half-life is 12h at low dose
25
Q
- Which of the following analgesics cause agranulocytosis
a. buprenorphine
b. phenylbutazone
c. flunixin
d. ketoprofen
A
b
26
Q
- Which of the following analgesics doesn’t have uricosuric effect
a. aspirin
b. phenylbutazone
c. ketoprofen
d. a and b
A
c
27
Q
- Which of the following analgesics reduces the volume of urine produced
a. buprenorphine
b. carprofen
c. medetomidine
d. phenylbutazone
A
d
28
Q
- Which of the following drugs have poor availability when they are administered orally
a. medetomidine
b. carprofen
c. oxicams
d. indomethacin
A
a
29
Q
- Which of the following drugs is slightly eliminated in ruminants
a. piroxicam
b. carprofen
c. phenylbutazone
d. xylazine
A
c
30
Q
- Which of the following effects could be attributed to therapeutic doses of acetaminophen
a. strong anti-inflammatory action
b. weak anti-inflammatory action
c. gastric irritation
d. increase of respiratory frequency
A
b
31
Q
- Which of the following analgesics can induce allergic reactions
a. morphine
b. acetaminophen
c. ketoprofen
d. a and b
A
d
32
Q
- Which of the following doesn’t irreversibly interfere with the platelet function
a. morphine
b. xylazine
c. aspirin
d. ketorolac
A
d
33
Q
- Which of the following drugs undergoes enterohepatic circulation in rats
a. buprenorphine
b. ketoprofen
c. etodolac
d. all of them
A
d
34
Q
- Which of the following drugs is useful for treating inflammation and neuropathic pain in rats
a. carprofen
b. etodolac
c. morphine
d. buprenorphine
A
b
35
Q
- Which of the following drugs have mainly COX-2 inhibitory activity in dogs
a. aspirin
b. deracoxib
c. carprofen
d. b and c
A
d
36
Q
- Which of the following drugs are propionic acid derivatives
a. ketoprofen
b. mefenamic acid
c. naproxen
d. all of them
e. neither of them
A
d
37
Q
- Which of the following drugs have efficacy against orthopedic and postoperative pain comparable with buprenorphine
a. ketoprofen
b. meloxicam
c. carprofen
d. all of them
A
d
38
Q
- True or False: Meloxicam has higher inhibitory COX-1 than inhibitory COX-2 activity in cats.
A
True
39
Q
- Which of the following drugs are not indicated for treatment of post-operative pain and osteoarthritis in dogs
a. pirocoxib
b. meloxicam
c. carprofen
d. flunixin
A
d
40
Q
- What of the following drugs have COX-1 selectivity in dogs and horses
a. Meloxicam
b. Flunixin meglumine
c. Deracoxib
d. Naproxen
A
b