Ch 9 Antianxiety Agents

Question 1

Sedative-hypnotic varies in CNS depression. It is

Answer 1

Dose dependant

Question 2

Sedative-hypnotic in a small dose results in

Answer 2

Mild CNS depression > sedation
(Reduction of ability and simple anxiety)

Question 3

Sedative -hypnotic large dose results in

Answer 3

Greater CNS depression > hypnotic (induces sleep)

Question 4

Classic sign of anxiety in the dental chair: white knuckle syndrome

Answer 4

Clutching the dental chair arms and getting white knuckles during Trx

Question 5

Most common antianxiety drugs

Answer 5

Benzodiazepines

Question 6

Diazepam is aka

Answer 6

Valium

Question 7

Valium is ___ lipid soluble, ____ onset and concentrated in adipose tissue prolonging the action

Answer 7

Highly lipid soluble ; quick onset

Question 8

Do Benzodiazepines easily cross the blood brain barrier and placenta to have CNS and adverse effects on the fetus

Answer 8

Yes

Question 9

Mechanism of action of benzodiazepines: enhance/facilitate action of the NT y-aminobutyric acid which is aka ?

Answer 9

GABA; an inhibitor in the CNS

Question 10

GABA acts as a ____ at benzodiazepine receptor sites, thus reducing anxiety

Answer 10

Agonist

Question 11

What are the behavioural effects of benzodiazepines

Answer 11

1. Reduce anxiety and panic (low dose)
2. Drowsiness and sleep (high dose)
3. Repeated dose reduce rapid eye movement (REM) sleep
4. usual dose reduction in stage 3&4 sleep
5. Long term use interferes with restorative sleep

Question 12

Clonazepam (klonopin) orally with other anti seizure drugs manages

Answer 12

Partial seizures
(Clonazepam is a benzodiazepine)