Ch. 567 - Goiter

Question 1

T/F Congenital goiter is SPORADIC

Answer 1

T

Question 2

Causes of congenital goiter

Answer 2

1) Fetal thyroxine synthetic defect 2) Antithyroid drugs or iodides during pregnancy

Question 3

T/F Goiter is almost always present in infants with neonatal Grave’s

Answer 3

T

Question 4

Should be considered when the goiter is lobulated, asymmetric, firm, or large to an unusual degree

Answer 4

Teratoma

Question 5

A moderate deficiency of iodine overcome by increased efficiency in the synthesis of thyroid hormone

Answer 5

Endemic goiter

Question 6

T/F Goiter is both a hypertrophy and hyperplasia

Answer 6

T

Question 7

Endemic goiter: Serum T4

Answer 7

Low

Question 8

T/F Endemic goiter: Clinical hypothyroidism is rare

Answer 8

T

Question 9

T/F Endemic goiter: Circulating T3 are increased

Answer 9

T

Question 10

MOST serious consequence of iodine deficiency

Answer 10

Endemic cretinism

Question 11

Endemic cretinism: Mentally retarded, deaf-mute, with disturbances in standing gait and pyramidal signs

Answer 11

Neurologic type

Question 12

T/F Myxedematous endemic cretinism: Delayed growth

Answer 12

T

Question 13

T/F Myxedematous endemic cretinism: Delayed sexual development

Answer 13

T

Question 14

T/F Myxedematous endemic cretinism: Absence of goiter

Answer 14

T

Question 15

Prevents iodine deficiency during future pregnancies for about 5 years when given to women as a single IM injection

Answer 15

Poppy seed oil

Question 16

How do iodides cause hypothyroidism

Answer 16

Inhibits organification of iodine and synthesis of thyroid hormone

Question 17

Wolff-Chaikoff effect

Answer 17

Inhibition of organification of iodine and synthesis of thyroid hormone by acute administration of large doses of iodide