Ch. 560 - Hyperpituitarism, Tall Stature, and Overgrowth Syndrome

Question 1

Young persons with open epiphysis + GH overporduction

Answer 1

Gigantism

Question 2

Closed epiphysis + GH overproduction

Answer 2

Acromegaly

Question 3

MCC of pituitary giganstism

Answer 3

Pituitary adenoma

Question 4

Cardinal feature of gigantism

Answer 4

Longitudinal growth acceleration sec to GH excess

Question 5

Coarse facial features, enlarging hands and feet

Answer 5

Pituitary gigantism

Question 6

Enlargement of distal parts of the body but manifestations of abnormal growth involve all portions

Answer 6

Acromegaly

Question 7

Circumference of skull increases, nose becomes broad, tongue is enlarged, coarsening of facial features

Answer 7

Acromegaly

Question 8

Early symptoms of acromegaly

Answer 8

Fatigue and lassitude (lack of energy)

Question 9

Elevated GH levels with usually no suppression by the hyperglycemia of a GTT

Answer 9

Acromegaly

Question 10

MC type of GH-secreting cells involved in childhood gigantism

Answer 10

Mammosomatotrophs; ~50% of gigantism patients also have marked hyperprolactinemia

Question 11

Gold std for diagnosis of GH excess

Answer 11

Failure to suppress serum GH to <5ng/dL after 1.75g/kg OGTT

Question 12

Oral glucose challenge to diagnose GH excess tests for

Answer 12

Ability of IGF-1 to suppress GH secretion

Question 13

Treatment of choice for well-circumscribbed pituitary adenomas that cause gigantism

Answer 13

Transsphenoidal surgery

Question 14

Highly effective pharmacologic treatment for patients with GH excess

Answer 14

Somatostatin analogs, ie Ocreotide

Question 15

Pharmacologic treatment for patients with both GH and prolactin oversecretion

Answer 15

Dopamine agonsits, eg Bromocriptine

Question 16

GH receptor antagonist that competes with endogenous GH for binding to GH receptor

Answer 16

Pegvisomant