Ch. 562 - Disorders of Pubertal Development

Question 1

Precocious puberty is defined by onset of secondary sexual characteristics before ___ in girls and ___ in boys

Answer 1

8, 9

Question 2

Central precocious puberty is aka

Answer 2

Gonadotropin-dependent or true precocious puberty

Question 3

Peripheral precocious puberty is aka

Answer 3

Gonadotropin-dependent or precocious pseudopuberty

Question 4

Central vs peripheral precocious puberty:

stems from hypothalamic-pituitary-gonadal activation

Answer 4

Central

Question 5

Central vs peripheral precocious puberty: No activation of the normal hypothalamic-pituitary-gonadal interplay

Answer 5

Peripheral

Question 6

Central precocious puberty is defined by ___ in girls and ___ in boys

Answer 6

Breast development before 8; testicular development (≥4mL) before 9

Question 7

T/F Majority of girls with central precocious puberty have an idiopathic form

Answer 7

T

Question 8

T/F Majority of boys with central precocious puberty have an idiopathic form

Answer 8

F, structural CNS abnormality can be demonstated in up to 75% of boys

Question 9

MC brain lesion causing central precocious puberty

Answer 9

Hypothalamic hamartomas

Question 10

3 main patterns of pubertal progression of precocious puberty

Answer 10

1) Most girls
(<6 onset) and large majority of boys: Rapidly progressive puberty characterized by rapid physical and osseous maturation leading to a loss of height potential 2) Some girls (>6 onset): Slowly progressive characterized by parallel advancement of osseous and linear maturation with preserved height potential 3) Small percentage: Spontaneously regressive or unsustained central precocious puberty

Question 11

Precocious puberty: Sex hormone concentrations are usually appropriate for stage of puberty in both sexes

Answer 11

T

Question 12

T/F Measurement of LH in serial blood samples obtained during sleep has greater diagnostic power than measurement in a single random sample

Answer 12

T

Question 13

Precocious puberty: Pharmacologic treatment

Answer 13

GnRH agonist

Question 14

GnRH stimulation test can be used to diagnose

Answer 14

Precocious puberty

Question 15

GnRH agonist or leuprolide stimulation test can be used to daisgnose

Answer 15

Precocious puberty