Ch 40 Flashcards
What is the prototype aminoglycoside
Gentamicin
What are the Pharmacotherapeutics of gentamicin
Treats serious infections
What are contraindications of gentamicin
Hypersensitivity
Pregnancy
Lactation
What are adverse effects of gentamicin
Neurotoxicity
Nephrotoxicity
Ototoxicity
Neuromuscular blockade
What are drug interactions of gentamicin
Acylxlovir Amphotericin B Cephalothin Cisplatin Cyclosporine Loop diuretics Prostaglandin synthetase inhibitors Vancomycin
What are core pt variables regarding gentamicin
Past medical history and any kidney problems
Ototoxicity to fetus, assess pregnancy status
How can one maximize therapeutic effects of gentamicin
Make sure that patients receive the full course as prescribed at around the clock intervals
Do not give at the same time as extended penicillin
How can one minimize therapeutic effects of gentamicin
Maintain Blood levels of gentamicin within a therapeutic margin that is very narrow.
Monitor for signs of Ototoxicity and nephrotoxicity
Gentamicin has very little effect on what type of organisms
Anaerobic microbes
What are lincosamides
They are very toxic drugs
Their use must be monitored and limited to situations with infections by bacteria with known sensitivity
What is the prototype lincosamides
( cleocin, cleocin pediatric)
What are the Pharmacotherapeutics of clindamycin
It treats aerobic gram positive cocci
It treats several anaerobic gram negative and gram positive organisms
What does clindamycin do
Suppresses protein synthesis
What are aminoglycosides
They have been used since 1944
They are effective in treating severe infections
There us is limited due to there risk for adverse effects
