Ch 3 Tissue Healing: Collagen

Question 1

Predominant structural collagen of the body

Answer 1

Type I Collagen

Question 2

Collagen that constitutes 80-85% of dermal collagen

Answer 2

Type I Collagen

Question 3

Collagen that’s prominent in mature scars, tendon, bone, dentin, joints

Answer 3

Type I Collagen

Question 4

Predominant component of hyaline cartilage (outer ear, end of nose, joint)

Answer 4

Type II Collagen

Question 5

Collagen not present in skin

Answer 5

Type II Collagen

Question 6

Collagen that’s found in nucleus pulposus external annulus

Answer 6

Type II Collage

Question 7

Collagen that is prominent in vascular and visceral structures (blood vessels, GI tract, liver, uterus) but absent in bone and tendon

Answer 7

Type III Collagen

Question 8

Collagen that constitutes 15-20% of dermal collagen

Answer 8

Type III Collagen

Question 9

Collagen that is abundant in embyronic tissues

Answer 9

Type III Collagen

Question 10

The first collagen deposited in wound healing (granulation tissues)

Answer 10

Type III Collagen

Question 11

Collagen found in basement membranes (base of epithelial, endothelial, and mesenchymal cells found in developing fetus), glomeruli of kidney nephron

Answer 11

Type IV (4) Collagen

Question 12

Collagen present in most tissues but never as a major component

Answer 12

Type V (5) Collagen

Question 13

Collagen that’s prominent in fetal membrane, cornea, heart valve, minor component of skin, and synovial membrane

Answer 13

Type V (5) Collagen

Question 14

Prevalent in most connective tissues

Answer 14

Type VI (6) Collagen

Question 15

May be involved in matrix and bone disorders

Answer 15

Type VII (7) Collagen

Question 16

Collagen that anchors filaments of lymphatic vessels

Answer 16

Type VII (7) Collagen

Question 17

Secreted by rapidly proliferating cells

Answer 17

Type VIII (8) Collagen

Question 18

Collage found in basement membranes and may provide a molecular bridge between different types of matrix molecules

Answer 18

Type VIII (8) Collagen

Question 19

Minor component of hyaline cartilage; vitreous humor (fluid of eye)

Answer 19

Type IX (9) Collagen

Question 20

Formed only in the epiphyseal growth plate cartilage

Answer 20

Type X (10) Collagen

Question 21

May have a role in angiogenesis and involved in matrix and bone disorders

Answer 21

Type X (10) Collagen

Question 22

Hyaline Cartilage

Answer 22

Type XI (11) Collagen

Question 23

Embryonic skin and tendon, periodontal ligament

Answer 23

Type XII (12) Collagen

Question 24

Endothelial cells

Answer 24

Type XIII (13) Collagen

Question 25

Fetal skin and tendons; similar to type I

Answer 25

Type XIV (14) Collagen

Question 26

Provides structural support and tensile strength for almost all tissues and organs of the body

Answer 26

Collagen

Question 27

A fibrous protein molecule consisting of three chains of amino acid coiled around one another in a triple helix

Answer 27

Collagen

Question 28

What type of stimuli is collagen in extracellular matrix of muscle and tendon sensitive to?

Answer 28

Mechanical

Question 29

What type of collagen organization contributes to strength of tendons?

Answer 29

Unidirectional or parallel bundles

Question 30

What type of collagen organization contributes to the flexibility of skin and rigidity of bone?

Answer 30

In random arrangements

Question 31

What type of collagen organization allows transmission of light in the cornea and vitreous?

Answer 31

Right angles

Question 32

What type of collagen organization allows for elasticity of blood vessels?

Answer 32

Tubular fashion

Question 33

What type of collagen organization impart tensile strength to collagen fibers and prevent slippage of molecules past one another under tension?

Answer 33

Cross-linked (thicker, stronger filamentous structures)

Question 34

Structural stability of the extracellular matrix is primarily a consequence of?

Answer 34

Collagen and the extent of cross linking

Question 35

What is the most common form of collagen?

Answer 35

Type I Collagen

Question 36

What type of collagen is assembled in a thick bundle that is structurally very strong and found in all body tissues in which it forms bundles together with other collagen types?

Answer 36

Type I Collagen

Question 37

What type of collagen is assembled into thin supporting filaments?

Answer 37

Type II Collagen

Question 38

What type of collagen has a half-life of about 3 months?

Answer 38

Type II Collagen

Question 39

What type of collagen allows maintenance of nutritive exchanges between degenerative external annulus and any healthy remaining tissue, possibly delaying or avoiding further degeneration?

Answer 39

Type II Collagen

Question 40

What type of collagen is assembled into thin filaments that make tissues strong but supple and elastic?

Answer 40

Type III Collagen

Question 41

What type of collagen is more prevalent in newborns?

Answer 41

Type III Collagen

Question 42

What type of collagen enhances wound tensile strength and is the main component of scar tissue that remains after repair is completed?

Answer 42

Type I Collagen

Question 43

What type of collagen occurs during the initial stages of tissue repair and secreted by fibroblasts?

Answer 43

Type III Collagen

Question 44

What type of collagen is not assembled into fibers and forms the basement membrane to which epithelial, endothelial, and certain mesenchymal cells are anchored?

Answer 44

Type IV (4) Collagen