Ch 3 Tissue Healing: Collagen Flashcards
Predominant structural collagen of the body
Type I Collagen
Collagen that constitutes 80-85% of dermal collagen
Type I Collagen
Collagen that’s prominent in mature scars, tendon, bone, dentin, joints
Type I Collagen
Predominant component of hyaline cartilage (outer ear, end of nose, joint)
Type II Collagen
Collagen not present in skin
Type II Collagen
Collagen that’s found in nucleus pulposus external annulus
Type II Collage
Collagen that is prominent in vascular and visceral structures (blood vessels, GI tract, liver, uterus) but absent in bone and tendon
Type III Collagen
Collagen that constitutes 15-20% of dermal collagen
Type III Collagen
Collagen that is abundant in embyronic tissues
Type III Collagen
The first collagen deposited in wound healing (granulation tissues)
Type III Collagen
Collagen found in basement membranes (base of epithelial, endothelial, and mesenchymal cells found in developing fetus), glomeruli of kidney nephron
Type IV (4) Collagen
Collagen present in most tissues but never as a major component
Type V (5) Collagen
Collagen that’s prominent in fetal membrane, cornea, heart valve, minor component of skin, and synovial membrane
Type V (5) Collagen
Prevalent in most connective tissues
Type VI (6) Collagen
May be involved in matrix and bone disorders
Type VII (7) Collagen
Collagen that anchors filaments of lymphatic vessels
Type VII (7) Collagen
Secreted by rapidly proliferating cells
Type VIII (8) Collagen
Collage found in basement membranes and may provide a molecular bridge between different types of matrix molecules
Type VIII (8) Collagen
Minor component of hyaline cartilage; vitreous humor (fluid of eye)
Type IX (9) Collagen
Formed only in the epiphyseal growth plate cartilage
Type X (10) Collagen
May have a role in angiogenesis and involved in matrix and bone disorders
Type X (10) Collagen
Hyaline Cartilage
Type XI (11) Collagen
Embryonic skin and tendon, periodontal ligament
Type XII (12) Collagen
Endothelial cells
Type XIII (13) Collagen
Fetal skin and tendons; similar to type I
Type XIV (14) Collagen
Provides structural support and tensile strength for almost all tissues and organs of the body
Collagen
A fibrous protein molecule consisting of three chains of amino acid coiled around one another in a triple helix
Collagen
What type of stimuli is collagen in extracellular matrix of muscle and tendon sensitive to?
Mechanical
What type of collagen organization contributes to strength of tendons?
Unidirectional or parallel bundles
What type of collagen organization contributes to the flexibility of skin and rigidity of bone?
In random arrangements
What type of collagen organization allows transmission of light in the cornea and vitreous?
Right angles
What type of collagen organization allows for elasticity of blood vessels?
Tubular fashion
What type of collagen organization impart tensile strength to collagen fibers and prevent slippage of molecules past one another under tension?
Cross-linked (thicker, stronger filamentous structures)
Structural stability of the extracellular matrix is primarily a consequence of?
Collagen and the extent of cross linking
What is the most common form of collagen?
Type I Collagen
What type of collagen is assembled in a thick bundle that is structurally very strong and found in all body tissues in which it forms bundles together with other collagen types?
Type I Collagen
What type of collagen is assembled into thin supporting filaments?
Type II Collagen
What type of collagen has a half-life of about 3 months?
Type II Collagen
What type of collagen allows maintenance of nutritive exchanges between degenerative external annulus and any healthy remaining tissue, possibly delaying or avoiding further degeneration?
Type II Collagen
What type of collagen is assembled into thin filaments that make tissues strong but supple and elastic?
Type III Collagen
What type of collagen is more prevalent in newborns?
Type III Collagen
What type of collagen enhances wound tensile strength and is the main component of scar tissue that remains after repair is completed?
Type I Collagen
What type of collagen occurs during the initial stages of tissue repair and secreted by fibroblasts?
Type III Collagen
What type of collagen is not assembled into fibers and forms the basement membrane to which epithelial, endothelial, and certain mesenchymal cells are anchored?
Type IV (4) Collagen
