Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Book - Elston > Ch. 3 - Malignant tumors of the epidermis > Flashcards

Ch. 3 - Malignant tumors of the epidermis Flashcards

1
Q

Actinic keratosis

A

Crowded, disordered, and atypical epidermal keratinocytes arising from a broad-budding basal layer. Usually with solar elastosis. Can have overlying “malignant horn” of parakeratotic stratum corneum.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Acantholytic actinic keratosis

A

Crowded, disordeed, atypical epidermal keratinocytes with acantholysis in areas of atypia. Can have overlying “malignant horn” and complex epidermal budding.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Lichenoid actinic keratosis

A

Crowded, disordered, atypical epidermal keratinocytes with areas of lichenoid interface dermatitis. Can have overlying “malignant horn”.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Hypertrophic actinic keratosis

A

Crowded, disordered, atypical epidermal keratinocytes with acanthosis. Often has complex epidermal budding. Has prominent overlying “malignant horn”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Bowenoid actinic keratosis

A

Focal full-thickness atypia without anaplasia, nesting, buckshot scatter, or full-thickness follicular involvement.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Bowen’s disease

A

Full-thickness atypia with loss of normal maturation. Follicular involvement, atypical nests, intraepidermal buckshot, malignant horn.

*essentially squamous carcinoma in situ)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Distinguish between Bowen’s disease and Paget’s disease or melanoma.

A

In Bowen’s disease, the malignant keratinize can keratinize and become part of the stratum corneum.

Bowen’s disease is PAS+ (diastase sensitive) and CEA- while Paget’s is PAS+ (diastase resistant) and CEA+.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Squamous cell carcinoma

A

Atypical keratinocytes invading the dermis with acantholysis and desmoplasia. Look for nodular lymphoid aggregates. Do keratin immunostaining,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Verrucous carcinoma

A

Well-differentiated glassy eosinophilic squamous epithelium with blunt, rounded borders.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Spindled squamous cell carcinoma

(differential diagnosis?)

A

Atypical spindle cells abutting the epidermis.

SLAM: Squamous cell carcinoma, leiomyosarcoma, atypical fibroxanthoma, melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Keratoacanthoma

A

Keratin-filled crater with invasive proliferation of glassy red keratinocytes. Neutrophilic & eosinophilic infiltrate. Hypergranulosis and pseudoepitheliomatous hyperplasia. Never acantholysis.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the natural history of keratoacanthomas?

A

Grow rapidly (especially after biopsy) and can involute spontaneously.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Distinguish between keratoacanthoma and squamous cell carcinoma.

A

Keratoacanthoma: Eosinophils and neutrophils. Central hypergranulosis and pseudoepitheliomatous hyperplasia. Terminal differentiation.

Squamous cell carcinoam: Plasma cells. Peripheral hypergranulosis and pseudoepitheliomatous hyperplasia. Invades eccrine glands.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Regressed keratoacanthoma

A

Crater filled with keratin and outlined by thin wall of involuted epithelium.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Basal cell carcinoma

A

Blue islands of basaloid cells with peripheral palisading. Retraction artifact and fibromyxoid stroma.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Superficial multifocal BCC

A

Multifocal blue buds with distinctive fibromyxoid stroma displacing solar elastosis downward.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Nodular BCC

A

Nodular blue islands with peirpheral palisading, retraction artifact, distinctive fibromyxoid stroma.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Micronodular BCC

A

Small blue islands with distinctive fibromyxoid stroma surrounding individual islands (but with normal dermis between). Aggressive worm-like growth.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Morpheaform BCC

A

Thin infiltrating strands of basaloid cells with sclerotic stroma and tadpole-like islands with small horn cysts.

Initially resembles scar but deeply invasive.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Infiltrative BCC

A

Spiky growth pattern, with fibroblast-rich stroma and common perineural extension. Resembles stroma of trichoepithelioma.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Infundibulocystic BCC

A

Pink strands and blue buds of tumor. Horn cysts and fibromyxoid stroma. Closely resembles basaloid follicular hamartoma.

22
Q

Fibroepithelioma of Pinkus

A

Anastomosing pink epithelial strands in ample fibromyxoid stroma with visible ducts. Blue basaloid buds at the tips and periphery of strands.

23
Q

Adenoid BCC

A

Blue islands with an adenoid pattern. Usual peripheral palisading, fibromyxoid stroma, and retraction artifact.

24
Q

Paget’s disease

A

Intraepidermal large cells with ample amphophilic cytoplasm. Atypical cells crush the basal layer and may “spit out” into the stratum corneum.

25
Q

Paget’s disease

(immunostaining)

A

CK7+

CEA+

S100-

PAS+, diastase resistant (sialomucin)

26
Q

Lymphoepithelioma-like carcinoma

A

Keratin-positive atypical epithelial cells with surrounding lymphocytes, mimics a germinal center or lymphoma. EBV-.

27
Q
A

Actinic keratosis

28
Q
A

Acantholytic actinic keratosis

29
Q
A

Lichenoid actinic keratosis

30
Q
A

Hypertrophic actinic keratosis

31
Q
A

Bowenoid actinic keratosis

32
Q
A

Bowen’s disease

33
Q
A

Bowen’s disease

34
Q
A

Bowen’s disease

35
Q
A

Clear cell change in Bowen’s disease

36
Q
A

Well-differentiated invasive squamous cell carcinoma

37
Q
A

Verrucous carcinoma

38
Q
A

Spindled squamous cell carcinoma

39
Q
A

Keratoacanthoma

40
Q
A

Regressed keratoacanthoma

41
Q
A

Superficial multifocal BCC

42
Q
A

Nodular BCC

43
Q
A

Micronodular BCC

44
Q
A

Morpheaform BCC

45
Q
A

Infiltrative BCC

46
Q
A

Infundibulocystic BCC

47
Q
A
47
Q
A

Fibroepithelioma of Pinkus

48
Q
A

Extramammary Paget’s disease

49
Q
A

Adenoid BCC

50
Q
A

Lymphoepithelioma-like carcinoma

Book - Elston (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions