Ch. 1 - Normal anatomy Flashcards

1
Q

Scalp skin

A

Numerous follicles extending into the panniculus with associated sebaceous glands and arrector pili muscle

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2
Q

Facial skin

A

Thin epidermis, basket-weave stratum corneum, demodex mites.

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3
Q

Truncal skin

A

Thick dermis, fewer adnexal structures but enveloped with projections of fat.

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4
Q

Areolar skin

A

Slight acanthosis, basilar hyperpigmentation, apocrine glands, smooth muscle bundles.

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5
Q

Acral skin

A

Compact eosinophilic stratum corneum and slight papillomatosis on dorsal surfaces

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6
Q

Volar skin

A

Compact eosinophilic hyperkeratosis with underlying stratum lucidum. Eccrine glands & meissner/pacinian corpuscles. No hair.

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7
Q

Eyelid

A

No hair follicles or stratum corneum, but goblet cells are present.

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8
Q

Mucosa

A

Absent granular layer, glycogenated keratinocytes, smooth muscle bundles and dilated vessels.

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9
Q

Nasal turbinate

A

Erectile tissue with fibrous septa, mucous glands, and vascular sinusoids

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10
Q

Fetal skin

A

Stellate and spindled fibroblasts (mesenchyme). Densely cellular.

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11
Q

Hair (infundibulum)

A

Most superficial (to sebaceous gland insertion). Keratinizes in the pattern of the normal epidermis with a granular layer. Intraepidermal portion is the “acrotrichium”

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12
Q

Hair (isthmus)

A

From sebaceous gland to insertion of arrector pili. Keratin formed without granular layer (trichilemmal keratinization). Inner root sheath lost at this level.

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13
Q

Hair (stem)

A

From insertion of arrector pili to Adamson’s fringe (where hair cornifies). Only present in anagen hairs.

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14
Q

Hair (bulb)

A

From Adamson’s fringe to base of follicle. Matrix, Supramatrix, and Keratogenous zones.

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15
Q

Nail anatomy (key features)

A

Nail plate, nail bed, framing portion, ensheathing portion (eponychium, hyponichium, solehorn, bed horny layer)

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16
Q

Cuticle

A

Visible cuticle (eponychium) is visible thick keratinous material that borders the proximal nail fold.

True cuticle is beneath the eponychium. Sometimes visible as flakes of keratinous material.

17
Q

Hyponychium, solehorn.

A

Hyponychium: Space, epithelium, and keratinous material ventral to the nail plate

Solehorn: Subungual white/colorless keratin

18
Q

Lunula

A

Visible portion of nail matrix

19
Q

Types of nail keratinization

A

Onychokeratinization (no granular layer, hard keratin)

Onycholemmal keratinization (ventral part of proximal nail fold)

Epidermoid keratinization (Dorsal and lateral proximal nail folds)

20
Q

Dermal dendrocyte

A

Macrophage-type APCs in the dermis. Usually XIIIa+, S-100+

21
Q

Giant cell subtypes

A

Foreign-body: Haphazard nuclei
Langerhans: Wreath-shape nuclei
Osteoclast-like: Haphazard and eccentric nuclei, deep pink and scalloped cytoplasm
Touton: Wreath-shape nuclei with foamy peripheral cytoplasm
Ringed siderophage: Touton giant cell with hemosiderin (seen in fibrous histiocytoma)

22
Q

Langerhans cell

A

Dendritic APC in epidermis and dermis. Reniform nucleus. CD1a+, S100+, langerin+. Contains birbeck granules.

23
Q

Mast cell

A

“Fried-egg” round and bluish cell with metachromic granules.