Ch. 23 - Vascular tumors Flashcards
Angiokeratoma
Hyperkeratotic/acanthotic collection of ectatic thin-walled vessels in the epidermis. “Bloody seborrheic keratosis”
Lmphangioma
Similar to angiokeratoma with lymph in vessels, but few erythrocytes. D2-40+
Nevus flammeus
Dilated capillary-sized vessels
Angioma serpiginosum
Dilated tortuous capillaries in dermal papillae and upper dermis. No alk-phos activity.
Venous lake
Irregular, thin-walled ectactic vessel. Blanches and collapses easily.
Glomus tumor
(IHC?)
Rows of round dark nuclei with little cytoplasm surrounding delicate vascular spaces.
SMA+ / CD31-
Glomangioma
One to two layers of round dark nuclei surrounding thick-walled vessels.
Pyogenic granuloma (lobular capillary hemangioma)
Eruptive lobular lesion with packed endothelial cells, ectatic vessels, erosion and crusting. Often impetiginized.
Bacillary angiomatosis
Not-very-lobular collection of inflammatory cells and vessels. Neutrophils and organisms present.
Cherry angioma
Capillary hemangioma with pink hyalinized vessel walls.
Infantile hemangioma
(IHC?)
Initially solidly packed, later ectatic vessels.
GLUT1+
Angiolymphoid hyperplasia with eosinophilia
Central thick-walled hobnailed vessels with peripheral smaller vessels. Nodular lymphoid aggregegates with eosinophils.
Kimura’s disease
Small vessels with deep lymphoid nodules with eosinophils and peripheral eosinophilia and elevated IgE.
Intravascular papillary endothelial hyperplasia of Masson (IPEH)
Recanalizing thrombus within a vascular space with papillary projections with hyalinized cores.
Arteriovenous malformation (arteriovenous hemangioma)
Thick- and thin-walled vessels. Thick-walled vessels tend to be central.
Targetoid hemosiderotic hemangioma (hobnail hemangioma)
Traumatized hemangioma with peripheral vascular proliferation surrounding existing vessels and adnexae.
Eccrine angiomatous hamartoma
Discrete lobules composed of capillaries, mature eccrine glands, and ducts.
Glomeruloid hemangioma
(associations?)
Capillary loops within a dilated vascular space, resembling a glomerulus.
(POEMS, Castleman’s disease)
Microvenular hemangioma
(association?)
Monomorphous, elongated blood vessels with small lumens surrounding pericytes
(occurs in POEMS syndrome)
Tufted angioam (angioblastoma)
“Cannonball” tufts of capillary-sized vessels in the dermis which expand slowly.
Kaposiform hemangioendothelioma
(association?)
Large lobules of spindled endothelial cells forming slit-like and staghorn vascular spaces. Deep-seated, can involve bone.
Kasabach-Merritt coagulopathy
Hemangiopericytoma
Starghorned vessels surrounded by a proliferation of spindle-cell pericytes. Probably a solitary fibrous tumor?
Spindle cell hemangioma (spindle cell hemangioendothelioma)
Solid area of spindle cells with alveolar spaces resembling hemorrhagic lung. Phleboliths.
Epithelioid hemangioendothelioma
Dilated vascular channels with solid epithelioid and spindle cell areas. Intracytoplasmic lumens and some atypia.
