Ch. 26 - Hypersensitivity Reactions (Turgeon): Table 26-1,2 (For Midterm) Flashcards
What is the type of reaction of hypersensitivity reaction type I?
Anaphylactic
What is the type of reaction of hypersensitivity reaction type II?
Cytotoxic
What is the type of reaction of hypersensitivity reaction type III?
Immune Complex
What is the type of reaction of hypersensitivity reaction type IV?
T cell-dependent
What is the immunnoglobulin involved in the hypersensitivity reaction type I?
IgE
What is the immunnoglobulin involved in the hypersensitivity reaction type II?
IgG, possibly other immunoglobulins
What is the immunnoglobulin involved in the hypersensitivity reaction type III?
Antigen-antibody complexes (IgG, IgM)
What is the immunnoglobulin involved in the hypersensitivity reaction type IV?
None
Is there a complement involved in the hypersensitivity reaction type I?
No
Is there a complement involved in the hypersensitivity reaction type II?
Yes
Is there a complement involved in the hypersensitivity reaction type III?
Yes
Is there a complement involved in the hypersensitivity reaction type IV?
No
These types of hypersensitivity reactions include reactions with antibodies
Hypersensitivity reaction type I - III
This type of hypersensitivity reaction is T-cell mediated.
Hypersensitivity reaction type IV
Complements are involved in these types of hypersensitivity reactions.
Hypersensitivity reaction type II and III
Complements are not involved in these types of hypersensitivity reactions.
Hypersensitivity reaction type I and IV
What are the cells involved in the hypersensitivity reaction type I?
Mast cells
Basophils
Granules (Histamines)
What are the cells involved in the hypersensitivity reaction type II?
Effector cells (macrophages, polymorphonuclear leukocytes)
What are the cells involved in the hypersensitivity reaction type III?
Macrophages
Mast cells
What are the cells involved in the hypersensitivity reaction type IV?
Antigen-specific T cells
This type of hypersensitivity reaction involves the basophils and granules such as histamine.
Hypersensitivity reaction type I
This type of hypersensitivity reaction involves effector cells such as macrophages and polymorphonuclear luekocytes.
Hypersensitivity reaction type II
This type of hypersensitivity reaction involves macrophages and mast cells.
Hypersensitivity reaction type III
This type of hypersensitivity reaction involves Antigen specific T cells.
Hypersensitivity reaction type IV
These types of hypersensitivity reaction involves the mast cells.
Hypersensitivity reaction type I and III
These types of hypersensitivity reaction involves the macrophages.
Hypersensitivity reaction type II and III
Are there cytokines involved in the hypersensitivity reaction type I?
Yes
Are there cytokines involved in the hypersensitivity reaction type II?
No
Are there cytokines involved in the hypersensitivity reaction type III?
Yes
Are there cytokines involved in the hypersensitivity reaction type IV?
Yes (T cell cytokines)
This is the only type of hypersensitivity reaction that does not have cytokine involvement.
Hypersensitivity reaction type II
The cytokines involved in this type of hypersensitivity reaction is the T cell cytokines.
Hypersensitivity reaction type IV
How is the hypersensitivity reaction type I mediated? (Comparative description)
Antibody mediated, immediate
How is the hypersensitivity reaction type II mediated? (Comparative description)
Antibody dependent
Complement or cell mediated
How is the hypersensitivity reaction type III mediated? (Comparative description)
Immune complex mediated (Immune complex disease)
How is the hypersensitivity reaction type IV mediated? (Comparative description)
T cell mediated, delayed type
This type of hypersensitivity reaction is antibody mediated.
Hypersensitivity reaction type I
This type of hypersensitivity reaction is complement or cell mediated.
Hypersensitivity reaction type II
This type of hypersensitivity reaction is immune complex mediated.
Hypersensitivity reaction type III
This type of hypersensitivity reaction is T cell mediated
Hypersensitivity reaction type IV
What is the mechanism of tissue injury in a hypersensitivity reaction type I?
Allergic and anaphylactic reactions
What is the mechanism of tissue injury in a hypersensitivity reaction type II?
Target cell lysis
Cell-mediated cytotoxicity
What is the mechanism of tissue injury in a hypersensitivity reaction type III?
Immune complex deposition
Inflammation
What is the mechanism of tissue injury in a hypersensitivity reaction type IV?
Inflammation
Cellular infiltration
The mechanism of tissue injury in this type of hypersensitivity reaction is allergic and anaphylactic reactions.
Hypersensitivity reaction type I
The mechanism of tissue injury in this type of hypersensitivity reaction is target cell lysis and cell-mediated cytotoxicity.
Hypersensitivity reaction type II
The mechanism of tissue injury in this type of hypersensitivity reaction is immune complex deposition
inflammation.
Hypersensitivity reaction type III
The mechanism of tissue injury in this type of hypersensitivity reaction is inflammation
cellular infiltration.
Hypersensitivity reaction type IV
The mechanism of tissue injury of these types of hypersensitivity reaction involves inflammation.
Hypersensitivity reaction type III and IV
Give examples of hypersensitivity reaction type I.
Anaphylaxis
Hay fever
Asthma
Food allergy
Give examples of hypersensitivity reaction type II.
Transfusion reactions
Hemolytic disease of newborn
Thrombocytopenia
Give examples of hypersensitivity reaction type III.
Arthus reaction
Serum sickness
Systemic lupus erythematosus
Give examples of hypersensitivity reaction type IV.
Allergy or infection
Contact dermatitis
Examples of this type of hypersensitivity reaction are anaphylaxis, hay fever, asthma, and food allergy.
Hypersensitivity reaction type I
Examples of this type of hypersensitivity reaction are transfusion reactions, hemolytic disease of newborn and thrombocytopenia.
Hypersensitivity reaction type II
Examples of this type of hypersensitivity reaction are arthus reaction, serum sickness and systemic lupus erythematosus
Hypersensitivity reaction type III
Examples of this type of hypersensitivity reaction are llergy or infection and contact dermatitis
Hypersensitivity reaction type IV
Give some mediators of anaphylaxis.
Histamines Leukotrienes Basophil kallikrein Serotonin Platelet-activating factor Eosinophil chemotactic factor of anaphylaxis Prostaglandins
The primary action of this mediator of anaphylaxis is to increase vascular permeability; promotes contraction of smooth muscle.
Histamines
The primary action of this mediator of anaphylaxis is to alter bronchial smooth muscle and enhance effects of histamine on target organs.
Leukotrienes
The primary action of this mediator of anaphylaxis is to generates kinins.
Basophil kallikrein
The primary action of this mediator of anaphylaxis is to contract smooth muscle.
Serotonin
The primary action of this mediator of anaphylaxis is to enhance the release of histamine and serotonin from platelets that affect smooth muscle tone and vascular permeability.
Platelet-activating factor
The primary action of this mediator of anaphylaxis is to attract eosinophils to area of activity; these cells release secondary mediators that may limit the effects of primary mediators.
Eosinophil
chemotactic factor of anaphylaxis
The primary action of this mediator of anaphylaxis affects smooth muscle tone and vascular permeability.
Prostaglandins