Ch. 2 - for Prelim exam Flashcards
This Ig accounts for about 10% of the Ig pool and is largely confined to the intravascular pool because of its large size. It is produced early in an immune response and largely confined to the blood.
IgM
This Ig is effective in agglutination and cytolytic reactions.
IgM
What are the normal values of IgM among males?
60 - 250 mg/dL (70 - 290 IU/mL)
What are the normal values of IgM among females?
70 - 280 mg/dL (80 - 320 IU/mL)
Adult levels of IgM are reached at what age?
8 to 15 years
At 4 months of age, how much of the adult levels of IgM is present?
50%
How much IgM is present in cord blood?
Greater than 20 mg/dL
IgM is detectable in cerebrospinal fluid. (T/F)
False
What is the major Ig in normal serum? When this Ig forms complexes, complement can be activated.
IgG
This Ig diffuses more readily than other immunoglobulins into the extravascular spaces and neutralizes toxins or binds to microorganisms in extravascular spaces.
IgG
This Ig can cross the placenta.
IgG
This Ig accounts for 70% to 75% of the total Ig pool and is a 7S molecule.
IgG
This subclass of IgG has a MW of 170,000 Da and is slightly larger than the others.
IgG3
This Ig class represent 15-20% of the total circulatory Ig pool. It is the predominant Ig in secretions such as tears, saliva, colostrum, milk, and intestinal fluids.
IgA
This Ig is synthesized largely by plasma cells located on body surfaces. If produced by cells in the intestinal walls, it can pass directly into the intestinal lumen or diffuse into the blood circulation
IgA
As IgA is transported through intestinal epithelial cells or hepatocytes, it binds to a glycoporotein called the _____. This protects IgA from digestion by gastrointestinal proteolytic enzymes. It forms a complex molecule termed _____.
Secretory components
Secretory IgA
The Ig class that accounts for less than 1% of the total Ig pool. It is extremely susceptible to proteolysis and is primarily a cell membrane Ig found on the surface of B lymphocytes in association with IgM
IgD
It is a trace plasma protein found in the blood plasma if unparasitized individuals.
IgE
The Ig class that is crucial because it mediates some types of hypersensitivity (allergic) reactions, allergies, and anaphylaxis and is generally responsible for an individual’s immunity to invading parasites.
IgE
This Ig molecule is unique in that it binds strongly to a receptor on mast cells and basophils and, together with antigen, mediates the release of histamines and heparin from these cells.
IgE
