Ch. 2 - for Prelim exam

Question 1

This Ig accounts for about 10% of the Ig pool and is largely confined to the intravascular pool because of its large size. It is produced early in an immune response and largely confined to the blood.

Answer 1

IgM

Question 2

This Ig is effective in agglutination and cytolytic reactions.

Answer 2

IgM

Question 3

What are the normal values of IgM among males?

Answer 3

60 - 250 mg/dL (70 - 290 IU/mL)

Question 4

What are the normal values of IgM among females?

Answer 4

70 - 280 mg/dL (80 - 320 IU/mL)

Question 5

Adult levels of IgM are reached at what age?

Answer 5

8 to 15 years

Question 6

At 4 months of age, how much of the adult levels of IgM is present?

Answer 6

50%

Question 7

How much IgM is present in cord blood?

Answer 7

Greater than 20 mg/dL

Question 8

IgM is detectable in cerebrospinal fluid. (T/F)

Answer 8

False

Question 9

What is the major Ig in normal serum? When this Ig forms complexes, complement can be activated.

Answer 9

IgG

Question 10

This Ig diffuses more readily than other immunoglobulins into the extravascular spaces and neutralizes toxins or binds to microorganisms in extravascular spaces.

Answer 10

IgG

Question 11

This Ig can cross the placenta.

Answer 11

IgG

Question 12

This Ig accounts for 70% to 75% of the total Ig pool and is a 7S molecule.

Answer 12

IgG

Question 13

This subclass of IgG has a MW of 170,000 Da and is slightly larger than the others.

Answer 13

IgG3

Question 14

This Ig class represent 15-20% of the total circulatory Ig pool. It is the predominant Ig in secretions such as tears, saliva, colostrum, milk, and intestinal fluids.

Answer 14

IgA

Question 15

This Ig is synthesized largely by plasma cells located on body surfaces. If produced by cells in the intestinal walls, it can pass directly into the intestinal lumen or diffuse into the blood circulation

Answer 15

IgA

Question 16

As IgA is transported through intestinal epithelial cells or hepatocytes, it binds to a glycoporotein called the _____. This protects IgA from digestion by gastrointestinal proteolytic enzymes. It forms a complex molecule termed _____.

Answer 16

Secretory components

Secretory IgA

Question 17

The Ig class that accounts for less than 1% of the total Ig pool. It is extremely susceptible to proteolysis and is primarily a cell membrane Ig found on the surface of B lymphocytes in association with IgM

Answer 17

IgD

Question 18

It is a trace plasma protein found in the blood plasma if unparasitized individuals.

Answer 18

IgE

Question 19

The Ig class that is crucial because it mediates some types of hypersensitivity (allergic) reactions, allergies, and anaphylaxis and is generally responsible for an individual’s immunity to invading parasites.

Answer 19

IgE

Question 20

This Ig molecule is unique in that it binds strongly to a receptor on mast cells and basophils and, together with antigen, mediates the release of histamines and heparin from these cells.

Answer 20

IgE