Ch. 23 Cancer Flashcards
metastasis
advanced tumors shed cells that travel to other parts of the body
Tumor growth
cells divide rapidly and constantly (crowd normal cells and rob nutrients)
Tumor suppressor genes
mutated recessive-acting inhibitory genes that cause cancer; cell division may be stimulated when inhibitory genes are made inactive
Oncogenes
mutated dominant-acting stimulatory genes that cause cancer- (have a stimulatory affect on the cell cycle)
Proto-oncogenes
oncogene prior to mutation; normal cellular gene responsible for basic ceullar function; when mutated they may become an oncogene
DNA repair genes
mutations in DNA-repair genes can increase the likelihood of acquiring mutations in these genes
If one or more required mutations are inherited…
less mutations would be required to produce cancer: Knudson’s Multistep Model
Most tumors arise from __________mutations
somatic mutations
The 1st mutation cell…
predisposed to proliferate faster
The 2nd mutation causes…
cells to divide rapidly
3rd mutation cell…
undergoes structural changes
The 4th mutation causes
cells to divide uncontrollably and invade outher tissue (malignant)
The rate of clonal evolution depends on…
the frequency with which new mutations arise
telomerase
activation of telomerase allows cells to divide indefinitely