Cervical cancer

Question 1

What histological type if cervical cancer?

Answer 1

Majority SCC

Can be adenocarcinoma

Question 2

What is the biggest etiological factor with cervical cancer?

Answer 2

> 90% HPV 16 and 18 related

Question 3

What is the mechanism by which HPV causes atypia?

Answer 3

Viral DNA integrates into host cell genome, leading to over expression of viral proteins and dysregulation of host cell cycle

Question 4

What are the risk factors for cervical cancer?

Answer 4

Multiple partners
Early age at first intercourse
Older age of partner
Smoking
Age 45-49

Question 5

What is the presentation of cerical cancer?

Answer 5

Abnormal bleeding- PCB, IMB, PMB
Discharge- watery, mucoid, purulent, malodorous
Rarely pain

Question 6

What is the screening for cervical cancer?

Answer 6

Every 3 years from 25-49 and every 5 from 50-64
Smear test for high risk HPV and/or cytology
If pregnant, arrange for 12 weeks post delivery

Question 7

How is cervical cancer diagnosed?

Answer 7

Biopsy

Imaging- MRI, CT

Question 8

How is cervical intraepithelial neoplasia managed?

Answer 8

LLETZ excision
Thermal coagulation
Laser ablation

Question 9

How is cervical cancer managed?

Answer 9

Excision
Hysterectomy
Chemoradiotherapy

Question 10

What is the prognosis for cervical cancer?

Answer 10

Relatively good