Cerebellum Flashcards

1
Q

What is the role of the basal ganglia in the context of movement

A
  • Receives input from widespread cortical areas, integrates this input and projects it back to the cortex
  • Encodes the decision to move, the direction and amplitude of movement and the motor expression of emotions
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2
Q

What connects the cerebellum to the medulla?

A

Inferior peduncles

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3
Q

What connects the cerebellum to the pons?

A

Middle peduncles

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4
Q

What connects the cerebellum to the midbrain?

A

Superior peduncles

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5
Q

Excitatory fibres of the cerebellum

A
  • Mossey fibres

* Climbing fibres

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6
Q

What are the layers of the cerebellum?

A
  • Molecular layer - parallel fibres, axons, sensory info
  • Purkinje cell - all in a straight line
  • Granule cell layer: granular cells, glomeruls, Golgi cells
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7
Q

Inhibitory fibres of the cerebellum

A
  • Golgi

* Purkinje

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8
Q

Input of the cerebellum

A
  • Inputs from the climbing fibres come up and synapse with the parallel fibres.
  • Mossey fibres brings sensory info and synapse on parallel fibres
  • Purkinje and Golgi are inhibitory
  • Spinocerebellar tracts
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9
Q

Which cell mediates learned movements

A

Purkinje

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10
Q

What sends signals to the red nucleus?

A
  • Deep cerebellar nuclei

* via rubrospinal tract

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11
Q

What are the deep cerebellar nuclei?

A
  • Dentate
  • Emboliform
  • Globose
  • Fastigial
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12
Q

What makes up the interposed nucleus?

A
  • Emboliform

* Globose

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13
Q

What are the roles of the cerebellum?

A
  • Acts as a comparator
  • Acts as a timing device
  • Initiates and stores movements
  • modulate motor output
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14
Q

Cerebellum as a comparator

A
  • Compares descending supra spinal motor signals with ascending afferent feedback information
  • So movement is smoothly and accurately coordinated
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15
Q

Cerebellum as a timing device

A
  • Pontocerebellum - Creates a sequence for motor activation
  • Vestibulocerebellum - maintains balance
  • Spinocerebellum - maintains posture
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16
Q

Cerebellum initiating and storing movements

A
  • Modifiable synapse (purkinje cells)

* Can store information and update it

17
Q

How does the cerebellum modulate motor output?

A
  • Activity of the pre motor and the motor areas as well as the spinal motor circuits
  • Sensory feedback from the vestibular system, visual system and ascending proprioceptive information
18
Q

What are the clinical features of cerebellar damage?

A
  • Hypotonia/reduced muscle tone
  • Incoordination/ataxia
  • Dysarthria
  • Nystagmus
  • Palatal tremor/ myoclonus
19
Q

Position of the macula

A
  • Vertical in the saccule

* Horizontal in the utricle

20
Q

What are otoliths?

A

Particles of calcium carbonate

21
Q

What are the semi-circular canals sensitive to?

A

Angular acceleration

22
Q

Describe the vestibulo-ocular reflex

A
  • Direct stimulation of ampullarf nerves elicits specific eye movements
  • Stimulation of afferents from left horizontal canal causes eye to turn right
  • Specific adaptation to allow gaze to remain steady during head movement
  • Lateral recti - cranial nerve VI
  • medial recti - cranial nerve III
23
Q

What is Menieres Disease?

A

• Excessive accumulation of the endolymph and damage to the hair cells

24
Q

What are the symptoms of Meniere’s disease

A
  • Vertigo
  • Nausea
  • Tinnitus
  • Hearing loss
25
Q

What is vertigo?

A

Sensation of turning or rotation in space in absence of actual rotation

26
Q

What are the causes of vertigo?

A
  • Debris from the otolithic membrane adhering to capital in ampulla of posterior semicircular canal
  • Lesions of vestibular aspect of CNVIII or central lesions affecting brainstem vestibular nuclei
27
Q

What are the clinical symptoms of vertigo?

A
  • Nausea
  • Vomiting
  • Gait ataxia
28
Q

What structures does the vestibular part fo the membranous labyrinth contain?

A
  • Otolith organs - detects gravity and head tilt

* Semicircular canal - detects head rotation