Central Nervous System Flashcards

1
Q

Where is white willow found?

A

Europe, moist habitats (riverbanks)

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2
Q

What has white willow bark been used for in the past?

A

chronic pain, fevers, headache, gout

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3
Q

Who provided a detailed account of the use of white willow bark for treating gastrointestinal pain and chronic inflammation?

A

Leonard Fuchs

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4
Q

What phenolics does white willow contain and what are their properties?

A

salicin and salicylic acid which have pyretic (fever reducing) and analgesic (pain relieving) properties, and salicylic acid is an anti-inflammatory agent

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5
Q

What are side effects of white willow phenolics?

A

gastric discomfort and nausea

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6
Q

What company investigated salicylic acid?

A

Bayer

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7
Q

What was the product called that Bayer semi-synthesized?

A

acetylsalicylic acid (ASA), patented as Aspirin

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8
Q

What are effects of ASA?

A

antipyretic, analgesic, and anti-inflammatory; also can reduce the risk of heart attack and stroke, and is an effective treatment for angina

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9
Q

Identifying traits of capsicum pepper

A

perennial herb, Solanaceae (tomato) family, native to South and Central America

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10
Q

What are the two varieties of pepper?

A

tabasco type, and habanero type

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11
Q

What causes the hotness of the capsicum pepper?

A

the proto-alkaloid capsaicin (concentrated where the seeds are)

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12
Q

Where is capsaicin absent?

A

seeds, leaves, stems, and roots

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13
Q

The burning sensation is caused by capsaicin binding to what receptors?

A

Vanilloid ion-channel receptors

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14
Q

What does the capsaicin binding result in?

A

A false signal sent to the brain that mimics the sensation of heat

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15
Q

Why are capsicum peppers popular?

A

The perception of pain stimulates the release of endorphins which results in a pleasurable sensation

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16
Q

What are the medicinal properties of capsaicin?

A

can be used as a topical analgesic to relieve pain for minor muscle aches, arthritis pain, and sprains; relief from skin rashes and psoriasis; and shingles
also has anti-fungal, anti-microbial and anti-cancer properties; kills prostate cancer cells and inhibits leukemia cell growth

17
Q

Identifying traits of valerian

A

herbaceous perennial native to Europe

18
Q

How did Ancient Greeks use valerian?

A

to treat digestive and urinary tract disorders

19
Q

What is the sedative effect of valerian root attributed to?

A

valepotriates (valerenic acid and valtrate) and a number of essential oils (terpenoids)

20
Q

What has valerian been used for historically?

A

first nervous afflictions (hysteric complaints) and an effective sedative for decreasing stress, anxiety, and sleep disorders; nervous tension; promotes sleep

21
Q

Identifying traits of St. John’s wort

A

European, perennial herb

22
Q

How was St. John’s wort used in Middle Ages?

A

Was said to have magical powers, and apparently repelled evil spirits. Folk healers have used it to treat depression, anxiety, and insomnia.

23
Q

What are the secondary products of St. John’s wort and how do they work?

A

hypericin and hyperforin; inhibit reuptake of 5 major neurotransmitters and hyperforin has antibiotic and anti-viral properties

24
Q

What drug does St. John’s wort outsell in Germany?

A

Fluoxetine (Prozac)

25
Q

Identifying traits of ginkgo

A

likely indigenous to China but is a cultigen, tree, distinct sexes

26
Q

How far back have ginkgo fossils been dated?

A

Jurassic period

27
Q

What was ginkgo used for in traditional Chinese medicine?

A

seeds were used to treat asthma, coughs, and bladder problems; leaves were used to improve blood circulation, treating skin disorders, and as a plaster to heal wounds

28
Q

What do ginkgo extracts do?

A

promotes vasodilation (opening of blood vessels) which improves blood flow and therefore treats short-term memory loss, arterial diseases (vericose veins), depression, cognitive problems and inner ear disorders

29
Q

What are ginkgo benefits to elderly patients?

A

improve memory, concentration, and overall alertness, reduced pain when walking, and relief from vertigo

30
Q

What are the active principles of ginkgo?

A

a group of related diterpenoids called the ginkgolides A-C; they are free radical scavengers that promote nerve cell viability, increase blood flow (preventing progress of dementia, which is caused by insufficient oxygen levels in the blood)

31
Q

Identifying traits of caucasian snowdrop

A

perennial, herbaceous, Daffodil family, native to Europe and west Asia

32
Q

How has the snowdrop been used medicinally?

A

treat muscle tissue disease, abnormal muscle weakness, and polio

33
Q

What’s the alkaloid in snowdrops and what does it do?

A

galantamine, inhibits acetylcholinesterase

34
Q

What is galantamine used for?

A

Treats Alzheimer’s disease, increases acetylcholine levels in the brain; enhances the memory of brain damage patients