Cellular Aberrations: Quiz 3 Flashcards
deviation from a normal functioning of the anatomy of a cell
aberrations
cell growth and spead unrestrained
Cancer
transformation from normal cell to neoplastic cell
Carcinogenesis
Most common cancers:
Lungs, Breast, Colon, Rectum
cancer is the most leading cause of epidemic non-communicable diseases at what place?
3rd
every Filipino dies because of cancer at what rate?
4
most caner in male
protstate
testicular cancer is most common in?
22-34 yrs old
cancer arise from epithelial tissue
Carcinoma
cancer arise from epithelial tissue
Carcinoma
cancer arise from supportive tissueq
Sarcoma
blood forming tissue
Leukemia
malignant neoplasm of lymphatic tissue
Lymphoma
cancer arise from plasma cells
myeloma
2 theories under pathogenesis
Cellular transformaton and derrangement theory
Failure of the Immune Response theoyr
5 steps of Carcinogenesis
IPLPI
Imitation
Promotion
Latency
Progression
Invasion of Neighboring organism
Etiologic factors caused by HPV, Hepa b and c, Cytomegalovirus
Oncovirus
Etiologic factors caused by H. Pylori to cause gastric cancer
Bacteria
Etiologic factors caused by fungi
mycotoxins , aflatoxin
Etiologic factors caused by chemical carcinogens
Sweetener, processed meats, red meats
Etiologic factors caused by physical
radiation, xray, trauma
Etiologic factors caused by hormones
estrogen
Etiologic factors caused by genetics,
oncogene-carcinogen-cell structure change- carcinoma
Etiologic factors caused by endogenous
hereditary
Etiologic factors caused by exogenous
carcinogens
FNAC
Fine needle Aspiration Surgery
Mitotic division produce a diploid number of
46 chromosomes.
Meiosis composed of haploid number of
23 chromosomes.
Derives from the latin ______ which means cancer.
crab
group of disorders characterized by abnormal
cell growth and the ability to metastasize with potential in killing the
host
Cellular Aberrations -
Occurs when cancer cells infiltrate adjacent tissues surrounding the
neoplasm.
INVASION
* Occurs wh
process whereby cells develop specific structures and function
is order to specialized in certain task.
DIFFERENTIATION
Increase in size of normal cells
*HYPERTROPY
Shrinkage of cell size
ATROPHY
- Increase in number of normal cells
HYPERPLASIA
Conversion from the normal pattern of differentiation
of one type of cells into another type of cell not normal for that tissue
METAPLASIA
Alteration in the shape, size, appearance, and
distribution of cells
DYSPLASIA
Disorganized, irregular cells that have no structure and
have lots of differentiation; the result is almost malignant.
ANAPLASIA -
conceptualizes that normal cells may be transformed into
cancer cells due to exposure to some etiologic agents
Cellular Transformation and Derangement Theory
advocates that all individuals possess cancer cells. However,
the cancer cells are recognized by the immune response
system.
Failure of the Immune Response Theory
defines the initiation of a tumor
CARCINOGENESIS
maintenance and subsequent evolution.
ONCOGENESIS
TX:
The primary tumor cannot be evaluated.
T0 (T zero):
no evidence of cancer in the colon or rectum.
Tis:
Refers to carcinoma in situ (cancer in situ).
T1
<2 cm
T2
2-4cm
T3
> 4cm
T4
> 4 cm, involved muscles, base of tongue or skin
N
(regional Lymph Node)
*Nx
cannot be assessed clinically
*NO –
no evidence of regular node metastasis
N1
Single, ipsilateral <3 cm
N2A
single, ipsilateral 3-6 cm
Multiple ipsilateral <6cm
N2B
N3
Massive ipsilateral, bilateral, contralateral
N3A
Ipsilateral nodes, one more than 6fcm
N3B
bilateral
N3C
contralateral
MX:
: Metastasis cannot be
measured.
M0
Cancer has not spread to
other parts of the body.
Cancer has spread to other
parts of the body.
M1:
Types of Metastasis (3)
Extension & Invasion
1. Lymphatic Spread
2. Seeding of body cavities & surfaces
3. Hematogenous spread
0
benign state
l
spread to nearby tissue
ii
2-5 cm sometimes involve lymph
III
more than 5 cm spread
(advanced spread to connective tissue)
Mestastasis
IV
ETIOLOGIC FACTORS (Carcinogens) 5
VCPHG
1.Viruses
2.Chemical carcinogens
3.Physical agents
4.Hormones
5.Genetics
induces pulmonary and pleural mesotheliomas in miners and industrial workers
Asbestos
WARNING SIGNAL OF CANCER
CAUTION
C- change in bladder and bowel habits
* A- a sore that does not heal
* U- unusual bleeding or discharges
* T- thickening or lump in the breast
* I - Indigestion and difficulty in swallowing
* O - overt changes in wart or mole
* N- nagging cough and hoarseness of voice