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Cell Bio 2 > cell matrix > Flashcards

cell matrix Flashcards

exam 2

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1
Q

connective tissue matrix components (4)

A

elastic fiber
proteoglycan
hyaluronan
Type I collagen

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2
Q

Basement membrane is the same as the

A

Basal Lamina

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3
Q

thin protein membrane based structure

A

Basement membrane

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4
Q

sugars on the proteoglycan create

A

a strong barrier

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5
Q

genetic defect causes deficinecy in copper utilization and thus faulty collagen crosslinking

A

Menke disease

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6
Q

Genetic defect in which Type IV collagen is absent or non-functional.

A

Alport syndrom

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7
Q

Collagen IV commonly found in

A

Basement membrane

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8
Q

second most common inherited PKD

A

Alport syndrome

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9
Q

autoimmunie disease in which antibodies to Type IV collagen destroy the basement membrane in the lung and kidneys

A

Goodpasture syndrome

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10
Q

20 kd fragment of Collagen XVIII

A

blood vessel-specific endostatin

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11
Q

endostatin is cleaved from

A

Collagen XVIII by an MMP

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12
Q

used in 4 million patients; endostatin, angiostatin and anti-VEGF antibody

A

angiogenesis

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13
Q

endostatin specificity

A

immature vascular endothelial cells

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14
Q

Endostatin likely mechanism

A

induces apoptosis in EC

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15
Q

ATP7A gene defect

A

menke

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16
Q

proteoglycan major function

A

provide selectively permeable filters in kidney and lung

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17
Q

more protein than carbohydrates and N-linked

A

glycoproteins

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18
Q

o-linked, huge amount of carbohydrates vs protein

A

proteogylcans

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19
Q

chondrodysplasias (2) causes

A

(1) defective chondroitin sulfate proteoglycans

(2) defective collagen II

20
Q

secreted by cell and remain tightly bounds to cell surface receptors, including integrins

A

matricellular proteins

21
Q

what are the major classes of matricellular proteins

A
  • fibronectins
  • laminins
  • CCN proteins
22
Q

Matricellular proteins often act as _______ to help regulate ______ and ___________ ________ for proliferation, motility and differentiation

A

Matricellular proteins often act as co-receptors to help regulate adhesion and signal transduction pathways for proliferation, motility and differentations

23
Q

epithelial cell matrix (basement membrane)

A

laminin

24
Q

another common adhesive protein that binds to integrins, heparan sulfates and collagens is

A

laminin

25
Q

laminin is a major component of

A

basement membranes

26
Q

key point of integrins

A

they are everywhere

27
Q

an inherited platelet integrin defect

A

Glanzmann’s

28
Q

elastin fibers are critical in

A

large arteries

29
Q

elastin fibers are critical in

A

large arteries

30
Q

mechanism of elastin-based stretch is through

A

fibrillin

31
Q

contracted “elastin”

A

low energy, high entropy

32
Q

defective fibrillin fails to cross-link elastin

A

marfan’s syndrome

33
Q

required for angiogenesis

A

MMPs

34
Q

cadherins are important in

A

junctions

35
Q

an inflammatory disease involving complex cell-cell and cell-matrix interactions

A

atherosclerosis

36
Q

atherosclerosis starts with

A

endothelial dysfunction

37
Q

fatty streak formation

A
  • foam-cell formation
  • T-cell activation
  • Smooth muscle cell migration
  • adherence and aggregation of platelets
  • adherence and entry of leukocytes
38
Q

advanced atherosclerosis

A
  • macrophage accumulation
  • formation of necrotic core
  • fibrous -cap formation
39
Q

unstable atherosclerotic plaques

A
  • how much blood flow is present

- rapidly forming plaque and rupture

40
Q

what control leukocyte adhesion to endothelium

A

CAMs and Matricellular Proteins

41
Q

leukocytes _____ along endothelium via weak “on-off” interactions of ______ on the leukocyte membrane with ____ on the endothelium

A

leukocytes roll along the endothelium via weak “on-off” interactions of carbohydrates on the leukocyte membrane with P-selectin on the endothelium

42
Q

P-selectin

A

matricellular protein

43
Q

Leukocytes _____ and ______ into inflamed areas due to PAF-activated _____ on the leukocyte binding strongly to _______ on the endothelium

A

Leukocytes stick and extravasate into inflamed areas due to PAF- activated integrins on the leukocyte binding strongly to ICAM-1 on the endothelium

44
Q

ICAM-1

A

cell adhesion molecule

45
Q

ATP7A is a

A

P-type ATPase

46
Q

which of the collagen-based diseases be managed by corticosteroids and other immunosuppressants

A

Goodpasture

47
Q

other major functions of proteoglycans (3)

A

(1) regulate hydration state of tissues, especially cartilage
(2) provide resistance to impact in cartilage
(3) Act as reservoirs for growth factors and cytokines

Cell Bio 2 (11 decks)

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