Cell birth and death III

Question 1

what is important during development?

Answer 1

apoptosis

Question 2

what happens in polycystic disease?

Answer 2

too much apoptosis

Question 3

what happens to chromatin during apoptosis?

Answer 3

it gets disorganized

Question 4

dna ladder

Answer 4

characteristic of apoptosis

Question 5

basic process of apoptosis (3)

Answer 5

induction
modulation
execution

Question 6

induction

Answer 6

physiologic, damage related, therapy associated

Question 7

2 major pathways induction

Answer 7

intrinsic and extrinsic

Question 8

Modulation

Answer 8

Bcl proteins

Question 9

intrinsic pathway only

Answer 9

Modulation

Question 10

execution

Answer 10

caspases followed by endonucleases

Question 11

directly responsible for blebbing

Answer 11

caspases

Question 12

caspases

Answer 12

cytoskeletal cleaving, and activate endonuclease

Question 13

inducers of apoptosis (3)

Answer 13

• physiological activators
• damage-related activators
• therapy associated

Question 14

endonucleases are responsible for what we see in the

Answer 14

DNA ladder

Question 15

can be both pro- and anti- apoptotic

Answer 15

Bcl family

Question 16

reveals the molecules and mechanisms

Answer 16

Burkitt’s lymphoma

Question 17

family members determines life and death

Answer 17

the ratio of pro- and anti- apoptotic Bcl family

Question 18

what happens at immunologically privileged sites

Answer 18

the vascular endothelial cells express Fas ligand

Question 19

mitochondrial pathway

Answer 19

intrinsic

Question 20

too much p53

Answer 20

go to apoptosis

Question 21

death recepto- intitated pathway

Answer 21

extrinsic

Question 22

Bcl family involved with _________ pathway

Answer 22

intrinsic

Question 23

lymphocytes expressing Fas receptor

Answer 23

undergo rapid apoptosis upon entering the privileged site

Question 24

withdrawal of growth factors, hormones is first step in

Answer 24

intrinsic pathway

Question 25

receptor-ligan interactions: Fas and TNF receptor is first step in

Answer 25

extrinsic pathway

Question 26

High TSH and low T3/T4

Answer 26

hypothyroidism

Question 27

what reduce neuronal damage after stroke

Answer 27

apoptosis inhibitors