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Cell Junctions Flashcards

(12 cards)

1
Q

What is the role of the extracellular matrix?

A

To take the mechanical stress of tension from the connective tissue.

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2
Q

What is the function of an epithelial cell?

A

To form a barrier and protect. Specialised for transport of substances.

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3
Q

What is an outstanding feature of epithelial cells?

A

No space inbetween other cells. Very little ECM. (Extracellular matrix)

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4
Q

How are neighbouring epithelial cells connected to each other?

A

Cell Junctions

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5
Q

What are the four major classes of cell-cell junctions?

A
  1. ) Anchoring
  2. ) Occluding
  3. ) Channel-forming
  4. ) Signal-relaying
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6
Q

Definition of an anchoring junction

A

Cytoskeleton of both cells combine to create a mechanical connection.

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7
Q

Two types of anchoring junctions are?

A

Desmosomes - IFs

Adherens junctions - Actin

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8
Q

What is cadherin?

A

Membrane protein used for anchoring junctions.

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9
Q

Purpose of cell adhesion molecules?

A

Promote cell-cell interactions

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10
Q

Purpose of tight junctions?

A

Prevent substances from moving through the ‘space’ in-between cells.

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11
Q

Which ion is required for a tight junction to function?

A

Ca2+

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12
Q

Purpose of a gap junction?

A

Allows adjacent cells to respond to intracellular signals.

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