Cell integrity Flashcards
What is the inner membrane folds called
Cristae
Where does oxidative phosphorylation take place
Inner membrane
What are the reoxidation equations of NADH and FADH2
Why can NADH generate multiple phosphoanhydride bonds when reoxidised
The delta G is much more negative than ATP hydrolysis
What is membrane protein complex 1
NADH dehydrogenase
What is membrane protein complex 2
Succinate dehydrogenase
Succinate-Q reductase
What is membrane protein complex 3
Q-cytochrome C oxidoreductase
What is membrane protein complex 4
Cytochrome c oxidase
What is mobile carrier co-enzyme A
Ubiquinone
What is the second mobile carrier
Cytochrome C
What coenzyme bypasses complex 1
FADH2
Why are fewer ATP moelcules generated from the reoxidation of FADH2
Less protons are pumped into the inter membrane space
What does a negative redox potential indicate
It has a tendancy to donate electrons
It has more reducing power than hydrogen
What happens to the electrons when they pass down the chain
Electrons lose energy
Which part of ATP synthase is membrane bound
F0
What is the lollipop head of ATPase called
F1
What is the cathode and equation of the oxygen electrode
Platinum
What is the anode and equation of the electrode
Silver
Graph of the suspension of mitochondria in the oxygen electrode
What are common failures of oxidative phosphrylation
Lack of oxygen
Hypoxia or anoxia
Death can be within a few minute (neurons) or a few hours (muscles)
Why are cyanide and azide metabolic poisons
They bind with high affinity to the Fe3 form of haem group in cytochrome oxidase complex
Why is malonate a metabolic poison
Competitive inhibitor to succinate dehydrogenase
Slows down oidation of succinate to fumarate
Why is rotenone a metabolic poison
Inhibits the transfer of electrons from complex 1 to ubiquinone
Why is oligomycin a metabolic poison
Inhibits oxidative phosphorylation by binding to the stalk of ATP syntahse and blocking the flow of protons
