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Pathology 1 Block 1 > Cell injury 3 (pictures) > Flashcards

Cell injury 3 (pictures) Flashcards

1
Q

What stage of necrosis is this?

A

pyknosis

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2
Q

What stage of necrosis is this?

A

Karyorrhexis

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3
Q

What stage of necrosis is this?

A

karyolysis

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4
Q

what type of necrosis is this? (what is distinctive?)

A

coagulative necrosis

tombstone appearance

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5
Q

what type of necrosis is this?

A

coagulative

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6
Q

what type of necrosis is this?

Where?

A

coagualtive necrosis in heart (myocardial infaction)

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7
Q

what type of necrosis is this?

what is distinctive?

A

coagulative necrosis

infarction (localized coagulative necrosis)

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8
Q

what type of necrosis is this?

A

coagulative necrosis of the kidney

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9
Q

what type of necrosis is this?

A

coagulative necrosis of the myocardium (MI)

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10
Q

what type of necrosis is this?

A

liquefactive necrosis (lung showing abscess )

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11
Q

what type of necrosis is this?

A

Liquefactive necrosis: Cerebral abscess

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12
Q

what type of necrosis is this?

A

Dry Gangrene: note “line of demarcation”

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13
Q

what type of necrosis is this?

A

Bowel ischemia: note darkened segments of bowel

(Wet gangrene)

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14
Q

what type of necrosis is this?

A

wet gangrene

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15
Q

what type of necrosis is this?

A

caseous necrosis

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16
Q

what type of necrosis is this?

A

caseous necrosis

17
Q

what type of necrosis is this?

A

fat necrosis

Red arrow: necrosis of fat cells. Black arrow: inflammatory cells.

18
Q

what type of necrosis is this?

A

fat necrosis: pancreas

19
Q

what type of necrosis is this?

A

fibrinoid necrosis

20
Q

fibrinoid necrosis usually occurs on what body part? how?

A

blood vessels through antigen-antibody complexes that deposit

21
Q

what type of necrosis is this?

A

fibrinoid necrosis

22
Q

what type of necrosis is this?

A

Fibrinoid Necrosis: Autoimmune disorder: Rheumatoid Arthritis

23
Q

where is this?

What is to be noticed here

A

Liver: apototic cells. Note, cell shrinkage, pyknotic nuclei. These cells may appear larger, due to retraction artifact (paleness around these cells). Retraction artifact happens while tissue processing.

24
Q

what is being acummulated in this picture?

what stain can be used to visualize fat?

when do we have increased fatty tissue in liver?

A

tryglycerides in liver

oil red O

causes: Reye’s synd., acute fatty liver of pregnancy, Jamaican vomiting disease, drugs.

25
what tissue is this? what is wrong? what is being accumulated?
myocardial tissue myocarditis fat
26
what are these? what is accumulated? when do we see it?
xanthomas cholesterol artherosclerosis or hereditary hyperlipedemia
27
what are these? what is accumulated?
xantomas cholesterol (note cholesterol clefts, macrophages filled with cholesterol)
28
what is this an example of accumulation of? where can they accumulate?
proteins (appear as eosinophilic droplets, vacuoles or aggregates in cytoplasm) ## Footnote - in proximal renal tubules: seen in renal diseases - immunoglobulin accumulation in plasma cell: **Russell bodies** **- defects in protein folding: amyloidosis**
29
what is this?
russel bodies
30
what is this an change example of? what is this type of change?
hyaline change - Intracellular accumulation of: protein droplet, Russell body, alcoholic hyaline (Mallory body)
31
what type of accumulation is seen here? how do we know?
glycogen, cells look purple --\> PAS stain
32
what is this photo an example of? what type is found in the picture?
exogenous pigment change anthracosis (carbon: air pollution)
33
what type of pigment change is this? what pigment is this? what is it made of? why is it important?
endogenous lipofuscin composed of lipids and phospholipids complexed with protein tells is there is damage through free radical injury and lipid peroxidation
34
what is this endogenous pigment? difference between this and lipofuscin? when is this seen locally? when is this seen systemically? what stain is used to see this?
hemosiderin this is hemoglobin derived (seen in hemoglobinopathies) local excess: hemorrhages in tissues (hematoma) systemic excess: iron overload (hemosiderosis) Prussian blue
35
what is this endogenous pigment? how does it form? what conditions do we see excess of it?
melanin when the enzyme tyrosinase catalyzes the oxidation of tyrosine to dihydroxyphenylalanine in melanocytes Addison’s disease, melanotic skin lesions
36
what is this endogenous pigment?
melanin
37
what is this an example of? what condition causes this?
Dystrophic calcification: demaged heart valve in Rheumatic valvular disease
38
what is this picture an example of? what is the name of the structures seen here? when do we see these?
Dystrophic calcification Psammoma bodies seen in: meningioma, papillary carcinoma thyroid, papillary carcinoma ovary

Pathology 1 Block 1 (12 decks)

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