Cell Growth And Division Flashcards
What are the 3 stages to interphase?
G1- growth 1
S- synthesis
G2- growth 2
Growth 1
Cell grows, metabolism is active, new proteins and RNA are made.
S phase
- processing (synthesis) of DNA
- DNA content doubles (info is copied)
G2 phase
- cell now contains twice as much DNA
- cell processes a substance that triggers cell
division to begin mitosis - enzymes released
M phase
- nucleus reproduces through a series of
events called mitosis - chromosomes become visible (condensed)
- not apart of interphase
What are the stages of the cell cycle?
- Interphase
- Mitosis
- Cytokinesis
How often do most eukaryotic cells divide?
Once every 24 hours
Chromosome
One long strand of DNA that consists of numerous genes along with regulatory info.
How many chromosomes are in our bodies?
46
Chromatin
Loose combination of DNA and proteins
Histones
DNA wraps around it at regular intervals, similar to beads on a string
Chromatid
1/2 of a duplicated chromosome
Sister chromatids
Two identical chromatid
Centromere
A region of the condensed chromosome that looks pinched
Telomeres
The ends of DNA molecules form structure
Spindle
Found in centrioles (only in animal cells), determines the direction of the cells during division.
What happens when the ratio of surface area to volume is too small?
The cell cannot move materials into and out of the cell at a sufficient rate or in sufficient quantities.
Does a cells volume increases as a cell grows?
Yes, more rapidly than its surface area
What are the stages of mitosis?
- prophase
- metaphase
- anaphase
- telophase
Prophase
- mitosis begins
- centrioles (poles) appear and begin to move
to opposite ends of a cell - spindle fibers form between the poles
- chromosomes condense
- nuclear membrane disappears
Metaphase
- Chromosomes move to the center of the cell
AKA the cell’s equator - chromatids attach to the spindle fibers
Interphase
- chromosomes are copied
- chromosomes appear as threadlike coils or
chromatin at the start, but each chromosome
and its copy (sister chromosome) change to
sister chromatids at end of this phase
Anaphase
chromatids separate and begin to move to
opposite ends of the cell
Telophase
- two new nuclei form
- chromosomes appear as chromatin
- chromosomes gather to opposite poles
- nuclear membrane forms around each group
of chromosomes - each nuclei contains a set of identical
chromosomes - mitosis ends
Cytokinesis
- cytoplasm divides into 2 parts
- cells are diploid (2n)
- cell membrane moves inward to create 2
daughter cells
What factors regulate cell division?
Internal and external
What are external factors?
Physical (cell contact) & chemical signals (growth factors)
What are growth factors?
Proteins that simulate cell division
- most mammal cells form a single layer in a
culture dish and stop dividing once they touch
other cells.
What are the internal factors?
Kinases & cyclins
Kinases
An enzyme (protein) that, when activated, transfers a phosphate group from one molecule to a specific target molecule. This changes the shape of a molecule.
Cyclin
A group of proteins that are rapidly made & destroyed at certain points I the cell cycle.
What factors trigger internal factors?
External factors
Apoptosis
- programmed cell death
- a normal feature of healthy organisms
- caused by a cell’s production of self
destructive enzymes - occurs in development of infants
Is cell division uncontrolled by cancer?
Yes
Tumors
Cancer cells formed in disorganized clumps
Benign tumors
Tumors that remained clustered and can be removed
Malignant tumors
Tumor that metastasize or break away and can form more tumors
Do cancer cells carry out necessary functions?
No
Carcinagers
Substances known to promote cancer (from the environment)
Standard cancer treatments
Typically kill both cancerous and healthy cells
Where do cancer cells come from?
Normal cells with damage to genes involved in cell cycle regulation
Oncogenes
Accelerate the cell cycle
What do most cancer cells carry mutations/errors in?
2 types of genes
How many chromosomes do daughter cells have compared to the original cell during meiosis?
Half as many
What does meiosis produce?
Gametes turn to 2 diploids turn to 4 haploids
Gametes
Eggs and sperm
Haploid cell
Where does meiosis occur?
Female
- ovaries or oogenesis
Male
- testes or spermatogenesis
In our germ cells that produce gametes