Cell Fate and Mapping

Question 1

Define fate

Answer 1

What cells will normally become during development

Question 2

Define fate map

Answer 2

A map of structures present at a given stage back onto an embryo at an earlier stage

Question 3

What does clonal analysis show?

Answer 3

Lineage of final cell types. What fates a cell can give rise to

Question 4

What are the progeny of a single labelled cell called?

Answer 4

A clone

Question 5

What makes up the ideal marker for a fate map?

Answer 5

• Readily visible at all stages
• Doesn’t perturb normal development
• Doesn’t leak into neighbouring cells
• Inherited by all the progeny of the labelled cells

Question 6

What can’t fate mapping tell us about?

Answer 6

Cell commitment

Question 7

How could you pinpoint when cells become committed to a fate?

Answer 7

Test by either transplantation or culture in isolation

Question 8

Mosaic development?

Answer 8

Cell fate is determined early

Question 9

Regulative development?

Answer 9

Cell fate is determined later on

Question 10

What is the term given for when the cell fate is determined early on?

Answer 10

Mosaic development

Question 11

What is the term given for when the cell fate is determined later on?

Answer 11

Regulative development