Cell cycle Flashcards
What are the stages of interphase?
G1
S
G2
What occurs in G1 phase?
Cell growth
What occurs in S phase?
DNA replication
What occurs in G2 phase?
cells duplicate organelles
What are the checkpoints of the cell cycle?
G1 checkpoint before S phase
G2 checkpoint before M phase
What happens to a cell if DNA damage is recognised?
apoptosis or enters G0 phase - arrests
What is the point of the checkpoints?
check for DNA damage
What does mitotic phase involve?
mitosis and cytokinesis
What are the phases of mitosis?
prophase, metaphase, anaphase and telophase
What happens at prophase?
nuclear membrane disappears, chromosomes condense and become visible
What happens at metaphase?
chromosomes align at metaphase plate and attach to spindle fibres at kinetochore
What happens at anaphase?
spindle fibres contract, pull sister chromatids apart to opposite poles of cell
What happens at telophase?
nuclear membrane reforms around new chromosomes, cytoplasm divides
What happens in cytokinesis?
cleavage furrow develops around equator region, cells separate - 2 daughter cells formed
What is non-disjunction?
when chromosomes fail to migrate properly in anaphase, one cell receives more chromosomes, one deficient