Cell Cycle

Question 1

What does PDGF do to the cell cycle

Answer 1

Allows the cell cycle to continue
Would attach to the receptor, send out a signal and would allow genes to be expressed and for there to be transcription and translation.
Rb would have the E2F Complex which would be released. Would have the E2F able to simulate cyclin and cod complex’s that would allow cell cycle to continue.
If Rb phosphorylated would then cause the cell cycle arrest

Question 2

What would the damaged DNA do to the cell cycle

Answer 2

Damage would allow the phosphorylation of P53, allowing it to be in its fully active form.
Would have the phosphorylated P53 would attach to P21
Transcription and translation would make a protein
Cause cell cycle arrest as the protein binds to cdk and cyclin complexes

Question 3

What are the checkpoints

Answer 3

G1
G2
M

Question 4

What cycling and cdk’s connect with the cell cycles points

Answer 4

D: G1
E: G1/S
A: S
B: M

Question 5

What activates the cyclin and cdk complex

Answer 5

Phosphorylation

Question 6

What inactivates RB

Answer 6

Phosphorylation

Question 7

What does pdgf do

Answer 7

Stimulates cell division

Question 8

What does the m phase check point check for

Answer 8

The adding of the kineticocore to the spindle fibres