Cell Adhesion & the ECM Flashcards
1
Q
Connective tissue elements x2
A
- Cells
- Extracellular matrix (ECM)
2
Q
Cells in connective tissue x4
A
- Fibroblasts
- Myofibroblasts
- Blood derived cells
- Adipocytes
3
Q
Elements in ECM x2
A
- Fibrillar proteins
- GAGs
4
Q
Function of fibroblasts
A
Secrete fibrillar proteins & GAGs
5
Q
2 main fibrous proteins
A
- Collagen
- Elastin
6
Q
Fibroblasts & collagen secretion
- how
- uses…
- effect
A
- Fibroblasts lay down fibrils in direction of others
- Fibripositor –> out of tunnels
- Fibrils are orientated along direction of tendon
7
Q
Elastin secretion
- main secretory cell
- also secreted by… x2
- structure x2
A
- Fibroblasts
- Smooth muscle cells
- Chrondroblasts
- Hydrophobic polypeptides
- Like to be in contact –> seek out & crosslink w each other
8
Q
Myofibroblasts
- function x2
- role in tissue damage
A
- Secrete fibrillar proteins (e.g. collagen)
- Contract –> as makes actin & myosin
- Make collagen scaffold –> forms fibrous scar –> contracts to reduce size of damaged area
9
Q
Mast cells
- structure
A
- Granules = contain histamine, heparin
10
Q
Plasma cells
- what
- function
A
- Modified B lymphocytes
- Make & secrete antibodies
11
Q
Macrophage
- function x2
A
- Phagocytosis
- Antigen processing & presentation
12
Q
Adipocytes
- function x3
A
- Insulation
- Packing
- Energy store
13
Q
Different cell junctions x4
A
- Tight junctions
- Adherens junctions
- Desmosomes
- Gap junctions
14
Q
Tight junctions
- tightness defined by… x3
- function x2
A
- Claudins, occludins, no. of sealing strands
- Form gates w varying degrees of closedness
- Fence off domains
15
Q
Adherens junctions
- connects to…
- how works
A
- Extracellular matrix
- Actin binds via adaptor protein to transmembrane protein (cadherin) = links to actin in another cell
