CD4

Question 1

What are the steps involved in antigen processing and presentation to CD4+ T cells?-

Answer 1

Antigen processing for CD4+ T cells involves

-Internalization of extracellular antigens,

-Degradation into peptides within endosomes or lysosomes,

-Loading onto MHC class II molecules, and

-Presentation on the cell surface for recognition by CD4+ T cells.

Question 2

What are the steps involved in antigen processing and presentation to CD8+ T cells?-

Answer 2

Antigen processing involves

-Degradation of intracellular proteins into peptides, which are then transported to the endoplasmic reticulum, loaded onto MHC class I molecules, and presented on the cell surface to CD8+ T cells for recognition.

Question 3

How are intracellular pathogens like virus antigens processing and presentation by DCs?-

Answer 3

Dendritic cells process viral antigens derived from intracellular pathogens like viruses and present them to T cells, initiating an immune response

Question 4

How are extracellular pathogens like bacterial antigens processing and presentation by DCs?-

Answer 4

Dendritic cells internalize extracellular bacterial antigens through phagocytosis, process them into peptides, and present these peptides on MHC class II molecules to activate CD4+ T cells.

Question 5

Proteasomal degradation of antigens involves which MHC class molecules and why?-

Answer 5

Proteasomal degradation of antigens primarily involves MHC class I molecules because they present peptides derived from intracellular proteins to CD8+ T cells for immune surveillance.

Question 6

Clip and HLA-DM mediated stability are related to which MHC class molecules

Answer 6

MHC class ||

Question 7

Explain the process of cross-presentation?

Answer 7

Cross-presentation is the culmination of complex subcellular processes that allow the processing of exogenous proteins and the presentation of resultant peptides on major histocompatibility class I (MHC-I) molecules to CD8 T cells.

Question 8

Sum the different professional antigen-presenting cells?

Answer 8

Professional antigen-presenting cells include dendritic cells, macrophages, and B cells, which specialize in capturing, processing, and presenting antigens to T cells to initiate immune responses

Question 9

What is length of peptides recognised by CD4+ T cells, and by which MHC class molecules are they presented?

Answer 9

12 to 16 AA