Case 20- Physiology and Anatomy Flashcards

1
Q

Decorticate and Decerebrate posturing

A
  1. Decorticate- damage to motor pathways above the level of the red nucleus: midbrain, internal capsule, cerebral hemisphere
  2. Decerebrate- damage at or below the red nucleus: brainstem, cerebellum, pons
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2
Q

Corticospinal pathway

A

Starts in the motor cortex decussates at the pyramids in the medulla and crosses over there.

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3
Q

Tectospinal pathway

A

Control head movement in response to visual stimuli i.e. tracking. From the superior colliculi, it crosses over (contralateral) and terminates in the cervical area

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4
Q

Rubrospinal pathway (minor in humans)

A

Excites flexor activity and inhibits extensor activity. Most input is via the cerebellum and so may regulate learned movement.

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5
Q

Reticulospinal pathway

A
  • Originates from the brain stem
  • Controls coordinate movement in muscles- maintenance of balance and muscle tone
  • Pontine and medullary reticulospinal tracts- originates in the oral and caudal pontine reticular nuclei (ipsilateral). Gigantocellular nucleus in the medulla (bilateral)
  • Many reticulospinal fibres shift from ventral to lateral funiculi when descending
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6
Q

Vestibulospinal tracts

A
  • Originate from the vestibular nucleus
  • Uncrossed
  • Sometimes split into lateral vestibulospinal tract and medial vestibulospinal tract
  • Lateral VST- regulating tone of muscles in posture and balance. Excites extensors, inhibits flexors- muscle tone
  • Medial VST- contact cervical motor neurones, head position, fixation of gaze (travels in medial longitudinal fasciculus)
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7
Q

Decorticate posturing

A
  • Involuntary flexion of upper extremities in response to external stimuli (excess red nucleus influence- RN only influences upper extremities)
  • The arms are flexed or bent inwards in the chest
  • The hands are clenched into fists
  • The legs extended and feet turned inwards
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8
Q

Decerebrate posturing

A
  • Involuntary extension of upper extremities in response to external stimuli- excess influence from the vestibulospinal tract through the pontine reticular nucleus
  • The head is arched back
  • The arms are extended by the sides and rotated internally
  • The legs are extended and rotated internally
  • The patient is rigid with their teeth clenched
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9
Q

Abnormal posturing

A

Input from cortex and cerebellum modulates the activities of these pathways. Lesions such as those caused by stroke, upset the balance of activity of these pathways. Lesions above the red nucleus cause decorticate posturing and excites flexors and inhibits extensors. Lesions between the red nucleus and vestibular nucleus cause decerebrate posturing as it looses influence from the red nucleus. Increased tone and rigidity over excitation of extensors and inhibition of flexors

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10
Q

Divisions of the skull

A

The skull is made up of 22 bones joined by sutures. It can be split into two parts:
• Neurocranium- the bony case covering the brain. Has a roof (calvaria) and a floor/base (basicranium)
•Viscerocranium- the facial skeleton

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11
Q

The Bones forming the neurocranium

A
  • Parietal bones (paired)
  • Temporal bones (paired)
  • Occipital bone (unpaired)
  • Parts of the frontal bone (unpaired)
  • Parts of the sphenoid bone (unpaired)
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12
Q

Structures of the vascerocranium (facial skeleton)- paired/unpaired

A
  • Nasal bones (paired)
  • Maxilla (paired)
  • Zygomatic bones (paired)
  • Lacrimal (paired)
  • Vomer (unpaired)
  • Palatine bones (paired)
  • Inferior nasal conachae (paired)
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13
Q

The ethmoid bone

A

The ethmoid bone is sometimes considered part of the neurocranium and in other parts the viscerocranium. It makes a minor contribution to the neurocranium but also forms part of the medial wall of the orbits and nasal cavity.

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14
Q

Important features on the ethmoid bone

A
  • Crista galli- is the attachment for the falx cerebri
  • Ethmoidal air cell- sinuses
  • Superior and middle nasal concha- extends into the nasal cavity
  • Perpendicular plate- forms the superior two thirds of the nasal septum
  • Cribiform plate- a sieve like structure which allows the olfactory nerve fibres to pass
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15
Q

The Zygomatic bones

A

The zygomatic bones form the check bones as they articulate with the temporal bones. When you are palpating the check bones you are touching the zygomatic arches.

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16
Q

The internal surface of the cranial base has 3 large depressions

A
  • Anterior cranial fossa- formed of the frontal, ethmoid and sphenoid bones
  • Middle cranial fossa- formed from parts of the sphenoid and temporal bones
  • Posterior cranial fossa- consists of parts of the temporal and occipital bones with small contribution from the sphenoid and parietal bones
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17
Q

Sutures

A

Sutures are a form of fibrous joint that are only found in the skull. They are immovable in adults and completely fuse by 20 years. The main sutures:
• Coronal suture- between the frontal bone and the two parietal bones
• Sagittal suture- between the parietal bones
• Lamboid suture- between the occipital bone and the parietal bones

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18
Q

Additional sutures

A
Take the name from the bones they are found between:
• Squamous suture
• Occipitomastoid suture
• Sphenosquamous suture
• Sphenofrontal suture
• Sphenoparietal suture
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19
Q

Craniometric points

A

Used to compare and describe the shape of the cranium and note variations:
• Pterion- junction of the sphenoid, temporal, frontal and parietal bones
• Lambda- junction of lamboid and sagittal suture. Site of the posterior fontanelle in neonates (typically closes at 2 months)
• Bregma- junction of coronal and sagittal suture. Site of the anterior fontanelle in neonates. (closes at approx. 18 months)

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20
Q

The pterion

A

Overlies the middle meningeal artery, a fracture in this area can injure the vessel. If the vessel is injured can accumulate between the skull and the dura mater forming an extradural haematoma

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21
Q

Parts of the Sphenoid bone

A

The body of the sphenoid sinuses which open into the nasal cavity via the ethmoid bone:
ethmoid bone. Parts of the Sphenoid bone:
• Body
• Greater wings- contributes to the floor of the middle cranial fossa, the lateral wall of the cranium and the orbit
• Lesser wings- slit like gap between the lesser and greater wings of the sphenoid- superior orbital fissure
• Pterygoid proces

22
Q

Sphenoid bone- body

A
  • The body of the sphenoid is found at the centre of the bone
  • It contains the sphenoidal sinuses
  • Its superior surface has the sella turcica present
23
Q

The Sella turcica

A

A saddle shaped depression which has three parts:
• Tuberculum sellae- forms the anterior wall of the sella turcica
• Hypophyseal fossa- the deepest part, this is where the pituitary gland sits
• Dorsum sellae- forms the posterior wall

24
Q

Sphenoid bone- Pterygoid process

A
  • The pterygoid processes extend inferiorly on each side of the sphenoid from the junction of the body and the great wing.
  • They are made up of a medial and lateral pterygoid plate.
  • The lateral and medial pterygoid muscles (muscles of mastication) originate from the lateral pterygoid plate.
25
Q

The parts of the Temporal bone

A
  • Squamous part- flat, plate-like part
  • Petrous part- pyramidal shaped area of bone containing the inner ear
  • Mastoid part- contains the mastoid process which is the site of attachment for the sternocleidomastoid muscle
  • Tympanic part- surrounds the external auditory opening (leads to the external auditory meatus)
26
Q

Temporal bones= Processes

A
  • Zygomatic process- articulates with the temporal process of the zygomatic bone to form the zygomatic arch (check bone)
  • Styloid process- attachment for various muscles and ligaments
27
Q

Temporal bone- ear

A
  • External acoustic (meatus) opening- the opening to the external acoustic meatus which leads to the tympanic membrane
  • Internal acoustic meatus (opening)- internal acoustic meatus is a narrow canal running in the petrous part of the temporal bone
28
Q

The Mastoid antrum

A

The mastoid antrum is a cavity continuous with collections of air filled spaces (mastoid air cells) throughout the mastoid part of the temporal bone, including the mastoid process. The air cells help to equalise pressure in the middle ear. The mucus membranes of the air cells are continuous with the middle ear so infection can easily spread causing Mastoiditis. Infection of the bone (osteomyelitis) may develop spreading to the middle cranial fossa.

29
Q

The key landmarks of the Occipital bone

A
  • Squamous part- articulates with the parietal bone at the lamboid suture, the temporal bones at the occipitomastoid suture
  • External occipital protuberance- attachment for the nuchal ligament and trapezius
  • Nuchal line
  • External occipital crest
  • Foramen magnum- spinal cord passes through the foramen magnum as well as the meninges, vertebral arterial, spinal arteries and spinal accessory nerve
  • Occipital condyles- articulates with C1
30
Q

Cranial foramina

A

Openings in the base of the skull which allow the passage of cranial nerves, blood vessels and other structures

31
Q

Foramina in the anterior cranial fossa

A

The anterior fossa is made up of the frontal, ethmoid and sphenoid (lesser wings) bones.

1) Cribriform plate- found in the ethmoid bone, it’s a sieve like structure. The olfactory nerve (CNI) passes through the cribiform plate.
2) Superior orbital fissure- between the anterior and middle cranial fossa. A diagonal gap between the greater wing and the lesser wing of the sphenoid.

32
Q

Contents of the superior orbital fissure

A
  • Oculomotor nerve (CNIII)
  • Trochlear nerve (CNIV)
  • Ophthalmic nerve (CNV1)
  • Abducens nerve (CNVI)
  • Ophthalmic veins
33
Q

Foramina in the middle cranial fossa

A
  • Optic canal= contains the Optic nerve (CN II), Opthalmic artery
  • Foramen rotundum= contains the Maxillary division of the Trigeminal nerve (CNV2)
  • Foramen ovale= contains the Mandibular division of the Trigeminal nerve (CNV3), Accessory meningeal artery
  • Foramen spinosum- contains the middle meningeal artery and vein. Branch of the mandibular division of the trigeminal nerve (CNV3)
  • Foramen Iacerum- closed off with cartilage
  • Carotid canal- internal carotid artery
34
Q

Middle cranial fossa

A

The middle cranial fossa is comprised of the sphenoid and the temporal bone

35
Q

The posterior cranial fossa

A

Made up of the temporal and occipital bones

36
Q

Foramina in the temporal bone (in the posterior cranial fossa)

A
  • Internal acoustic (auditory) meatus= Located in the petrous part of the temporal bone. Connects the posterior cranial fossa to the inner ear. Contains Facial nerve (CNVII), Vestibulocochlear nerves, Labyrinthe artery. Foramina in the temporal bone
  • Foramen magnum- in the occipital bone. Contains the Spinal cord, vertebral arteries, Meninges and the Spinal roots of the accessory nerve (CNXI)
  • Jugular foramen- within the occipital bone. Contains the inferior petrosal sinus, Glossopharyngeal nerve (CNIX), Vagus nerve (CNX), Spinal accessory nerve (CNXI), Sigmoid sinus (forming the internal jugular vein)
  • Hypoglossal canal- in the occipital bone. Contains the Hypoglossal nerve (CNXII), Marginal branch of the ascending pharyngeal artery
37
Q

Flexor and extensor muscles in the arm

A

Flexor muscles in the arms= Biceps brachii, Brachialis

Extensor muscles in the arms= Triceps brachii, Anconeus

38
Q

Muscle coordination

A
  • Muscles can only produce movement by contraction i.e. by pulling on a joint
  • Flexion- contract flexors and relax extensors
  • Extension- contract extensors and relax flexors
  • Muscles that pull in the same direction- Synergists
  • Muscles that pull in the opposite direction- Antagonists
  • Brachialis and Biceps= synergists, flexion
  • Biceps and triceps= antagonists
39
Q

Motor unit

A

A motorneuron and the muscle fibres it innervates. Each muscle fibres only receives input from one motor neurone. But a single motorneuron can innervate several muscle fibres

40
Q

Large motor unit

A
  • Each motoneuron innervates many muscle fibres
  • Provides strong force, but little precision
  • Common in Antigravity muscles legs or arms for lifting and holding weight
41
Q

Small motor unit

A
  • Each motoneuron innervating only a few fibres
  • Fine control, more precision
  • Lots in finger muscles for manipulating objects
42
Q

Alpha motor neurone i.e. lower motor neurones

A
  • Large neurons, Located in the ventral horn of the spinal cord
  • Motor neurons can innervate one or more muscle fibres the fewer fibres a neuron innervates, the finer the control
  • Motor neurons summate input from many different sources (e.g. upper motor neurons, interneurons, and several different types of sensory neurons) in order to ‘decide’ whether a muscle fibre needs contracting or relaxing. Note that a decrease in firing by the lower motor neuron will result in the relaxation of the innervated muscle fibres.
  • When an alpha (lower) motor neuron increases its firing the muscle fibre it innervates will contract. So the lower motor neuron ultimately decides whether the muscle fibre contracts or not
43
Q

Neurones that innervate muscles

A

Alpha motorneurons i.e. lower motoneurones. They are large neurones located in the ventral horn of the spinal cord

44
Q

Reflexes

A
  • Withdrawal, flexion reflex- removes body from painful stimulus.
  • Crossed extension reflex- compensates, enhances postural support. It’s a simplified circuit the interneurons are missed out. You have ascending/descending pathways
  • Stretch reflex- triggered by muscle spindle.
  • Golgi tendon reflex- triggered by golgi tendon organ in muscle tendon
45
Q

Muscle spindle and Extrafusal muscle fibres

A

Muscle spindle- receptor type composed of intrafusal fibres which run in parallel with extrafusal fibres. Involved in proprioception. Receive information from gamma motor neurones. The sensory fibres are Ia afferents and II afferents. Contains a mechanoreceptor which is wrapped around the extrafusal fibres and detect stretch
Extrafusal muscle fibres- these do the work of contraction

46
Q

Golgi tendon organ

A

Receptor type in series with extrafusal fibres
• Muscle stretches
• Increased afferent signals to the spinal cord
• Increased efferent output through alpha motor neurones
• Muscle contracts
• Firing rate of afferent sensory neurone decreases

47
Q

Ia and II sensory nerve fibres

A

Ia sensory nerve fibre- Phasic response, velocity. Thicker neurone, faster response. Involved in stretch reflex (muscle spindle)
II sensory nerve fibre- Tonic firing, sustained response, degree of stretch. Thinner neurone, slower response. Sends stretch message to the brain

48
Q

Role of the Ia sensory nerve fibres

A

Passive stretch causes increased activity from the Ia sensory fibre. Activation of the alpha motor neurones then causes resistance and muscle contractions decreasing the firing rate of the Ia sensory nerve fibre. The synergist muscles contract and the antagonist muscle relax.

49
Q

Muscle spindle receptor, Gamma motor neurones, Golgi tendon organs

A

1) Muscle spindle receptor- Negative feedback system, sensitive to muscle fibre length. Monitors and maintains muscle length.
2) Gamma motor neurones- innervates muscle spindle fibres, controls sensitivity. Activity is influenced by upper motor neurones and spinal cord circuitry.
3) Golgi tendon organs- involved in proprioception, present at junction muscle/tendon. Each organ is related to sensory Ib fibre (slightly smaller than Ia). The sensory nerve fibre is Ib Afferent

50
Q

Golgi tendon reflex

A
  • Negative feedback system
  • Less sensitive than muscle spindles
  • Respond to tension from muscle contract
  • Monitor and maintain muscle force