Cartilage and bone questions Flashcards
What are the principal components of the ECM of cartilage?
Proteoglycan aggregates and type II collagen
What are the major glycosaminoglycans in the ECM of cartilage?
Chondoitin sulfate 4&6
Keratan sulfate
Which component of the ECM is responsible for the ability of cartilage to absorb compressive force?
Type II collagen
Why is the cytoplasm of an active chrondocyte basophilic?
?
In which layer of the perichondrium would you expect to find chrondroblasts?
Chondrogenic layer
Chondrocytes end up in the Lacunae
Isogenous groups of chondrocytes are the result of
Mitosis
Why does cartilage have a poor potential for repair after injury?
Lack of blood supply
List two places in the body where hyaline cartilage can be found
Nose
Trachea
Bronchi
epiphyseal plate
What is responsible for the basophilia of the ECM of hyaline cartilage?
rich in glycosaminoglycans (GAGs)
the major fiber type in elastic cartilage can be selectively stained with
orcein dyes
Most of the collagen in fibrocartilage is type
I
Does interstitial growth occur within bone?
No
Another name for spongy bone is
Trabecular/cancellous bone
Both chondrocytes and osteocytes reside within small specs in the ECM. these spaces are called
Lacunae
In a typical long bone, where is compact bone located?
Around cancellous bone (spongy)
what part of an osteocyte extends into the canaliculi?
Filopodial process
What specialization for cell-cell attachment is resent at the points of contact btwn adjacent osteocytes?
Gap junctions
What is considered the be the main structural unit of compact bone?
Haversian systems- osteons
Interstitial lamellar systems represent
Angular fragments of lamellar bone
What covers or lines all of the internal surfaces of bone?
Endosteum
The process by which bone is constantly being broken down and replaced is known as
Osteoporosis
the presence of a ruffled border is characteristic of
osteoclasts
which is the only bone cell that is completely surrounded by ECM
Osteoblasts/osteocytes
