Cartilage and bone questions Flashcards

1
Q

What are the principal components of the ECM of cartilage?

A

Proteoglycan aggregates and type II collagen

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2
Q

What are the major glycosaminoglycans in the ECM of cartilage?

A

Chondoitin sulfate 4&6

Keratan sulfate

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3
Q

Which component of the ECM is responsible for the ability of cartilage to absorb compressive force?

A

Type II collagen

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4
Q

Why is the cytoplasm of an active chrondocyte basophilic?

A

?

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5
Q

In which layer of the perichondrium would you expect to find chrondroblasts?

A

Chondrogenic layer

Chondrocytes end up in the Lacunae

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6
Q

Isogenous groups of chondrocytes are the result of

A

Mitosis

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7
Q

Why does cartilage have a poor potential for repair after injury?

A

Lack of blood supply

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8
Q

List two places in the body where hyaline cartilage can be found

A

Nose
Trachea
Bronchi
epiphyseal plate

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9
Q

What is responsible for the basophilia of the ECM of hyaline cartilage?

A

rich in glycosaminoglycans (GAGs)

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10
Q

the major fiber type in elastic cartilage can be selectively stained with

A

orcein dyes

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11
Q

Most of the collagen in fibrocartilage is type

A

I

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12
Q

Does interstitial growth occur within bone?

A

No

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13
Q

Another name for spongy bone is

A

Trabecular/cancellous bone

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14
Q

Both chondrocytes and osteocytes reside within small specs in the ECM. these spaces are called

A

Lacunae

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15
Q

In a typical long bone, where is compact bone located?

A

Around cancellous bone (spongy)

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16
Q

what part of an osteocyte extends into the canaliculi?

A

Filopodial process

17
Q

What specialization for cell-cell attachment is resent at the points of contact btwn adjacent osteocytes?

A

Gap junctions

18
Q

What is considered the be the main structural unit of compact bone?

A

Haversian systems- osteons

19
Q

Interstitial lamellar systems represent

A

Angular fragments of lamellar bone

20
Q

What covers or lines all of the internal surfaces of bone?

A

Endosteum

21
Q

The process by which bone is constantly being broken down and replaced is known as

A

Osteoporosis

22
Q

the presence of a ruffled border is characteristic of

A

osteoclasts

23
Q

which is the only bone cell that is completely surrounded by ECM

A

Osteoblasts/osteocytes