CARTILAGE Flashcards
Tissue =
Cells and Extracellular matriX
ECM OF CARTILAGE IS RICH IN
chondroitin sulfate
fibers of cartilage, what collage
type II collagen
one of the glycosaminoglycan that allow cartilage to withstand compression
chondroitin sulfate
Synthesize the fibers and ground substance
CHONDROCYTES
Bone, tendon, skin, dentin
type 1 collagen
type 1 collagen funciton
resistance to tension
collagen type 2 tissues
cartilage, vitreous body
type 2 collage is _______ not easily seen under the miscroscope
highly refractile
function of collagen type 2
resistance to pressure
collagen type 3 tissue
reticular fibers
collagen type 3 function
supports parenchyma of organs
collagen type 4 tissues
basement membrane
collagen type 4 funciton
sheet-forming collagen
collagen type 7 tissue
basementmembrane
collagen typ e7 function
anchors basal lamina to reticular lamina
The matrix immediately surrounding the lacunae
is more intensely BASOPHILIC
TERRITORIAL MATRIX
This is due to the masking of the collagen fibers
by the high concentration of the
____________ in the ground substance. (basophilia)
glycosaminoglycans
retains water thus allowing
cartilage to act as shock absorber.
Ground substance
why prone to OA?
chondrocyte no longer produce ECM
FUNCTIONS OF THE CARTILAGE
Shock absorber
Provide framework and support
Protects underlying tissue
Provides flexibility
Provides template for bone formation
Dense irregular connective
tissue covering of
cartilages
perichondrium
perichondrium 2 layers
fibrous
chondrogenic
Chondroblasts in perichondrium differentiate into chondrocytes, start producing matrix, and add to existing cartilage beneath the perichondrium.
Appositional Growth:
proliferation and hypertrophy of existing chondrocytes.
It occurs within the cartilage.
Chondrocytes will divide (mitosis) producing isogenous aggregates that deposites ECM making chondrocytes move away from each other.
Interstitial growth
Hyaline:
Nuclei:
formation:
Elliptical shape at periphery
isogenous cell groups
Similar to hyaline cartilage except that is
contains abundant network of elastic fibers
ELASTIC CARTILAGE
elastic cartilage is elastic fibers +
collagen II
Elastic cartilage is found in
Ear (auricle)
Epiglottis
Eustachian tube
skinfold of the ear is made up of what epithelium
stratified squamous keratinized epithelium
ntermediate between dense connective tissue
and hyaline cartilage
FIBROCARTILAGE
Rich in collagen 1
FIBROCARTILAGE
toughest among all collagen
collagen 1
Fibroblast: Chondrocytes occur singly or ____ isogenous
aggregates
aligned
_____immediately surrounding the
chondrocytes has type 2 collagen
Matrix
Isogenous aggregates of chondrocytes are separated by _____ collagen fibers
type 1
Chondrocytes are ________ and with ___ metabolic rate
immobile; low
extensive damage causes the perichondrium to produce a scar of _____ connective tissue
dense
outer fibrous layer will cause the _________ to deposit collagen fibers in the collagen tissue forming a scar
fibroblast
