Cartilage Flashcards
1
Q
3 types of cartilage
A
- Hyaline
- Elastic,
- Fibrocartilage
2
Q
Hyaline cartilage fxn and location
A
- Aides in sliding within joints and provides a model for later bone growth
- Airway structural support including the larynx and cricoid cartilage in trachea
3
Q
Fibrocartilage overview
A
- Cells lined up in rows
- More collagen fiber content than others
- No perichondrium
4
Q
Fibrocartilage fxn and location
A
- Provides cushioning, strength and resists tearing and compression
- within IVD, meniscus, and pubic symp
5
Q
Elastic cartilage
A
- Elastin fibers as part of the ECM
- Provides flexible shape and support to soft tissues
- External ear, epiglottis
6
Q
Chondrocytes are embedded
A
-in lacunae, pockets of ECM
7
Q
Isogenous groups
A
-multiple chondrocytes in the same lacunae derived from the same mother cell
8
Q
Territorial matrix
A
ECM around lacunae
9
Q
Intraterritorial matrix
A
-ECM between perichondrium and chondrocyte layer
10
Q
Cartilage fibers
A
- Bonds between type II collagen, hyaluronan, and sulfates GAG on dense proteoglycans
- All cartilage types are relatively a vascular, receiving nutrients by diffusion from surrounding CT
11
Q
Most important role of collagen
A
Shock absorber
12
Q
Cartilage development
A
- Mesenchyme proliferates and differentiates into chondrocytes
- Chondrocytes produce ECM
- Cells disperse within ECM
- Individual chondrocytes undergo mitosis to form isogenous cell groups
13
Q
Articular Cartilage
A
- Hyaline cartilage forms it
- Smooth, Low-friction interface
- Synovial fluid allows nutrients and waste product to circulate between non-vascular cartilage and CT vasculature
- Articular Cartilage has low metabolic activity, so heals slowly and slow turn over
14
Q
Why does Articular cartilage heal slowly
A
-Low metabolic activity
15
Q
What stimulates growth and inhibits growth of cartilage
A
- Stim: Growth hormone and thyroid hormone
- Inhibit: adrenal stress hormones; that’s why being stressed is bad for cartilage healing
