Adipose Flashcards
1
Q
Adipocytes usually within
A
- Loose or dense irregular CT
- Large around abdominal organs
2
Q
Dietary fats are brought to cells via circulation as
A
Chylomicrons
3
Q
Lipids synthesized in the liver and transported in blood with
A
VLDLs, free FA, and glycerol
4
Q
Lipids are mobilized from adipocytes by
A
Hormone sensitive lipase, activated by NE release
5
Q
Adipose and embryology
A
- Born with stores of white adipose, accumulated by the 14th week of gestation
- Adipose increases by filling existing adipocytes until around 10
- New adipocyte formation occurs around small blood vessels where mesenchymal cells are most abundant
6
Q
Adult onset obesity
A
-Mainly involves increasing the size of existing adipocytes
7
Q
Beige adipocytes
A
- remain within white adi
- in colder temps, beige can change reversibly, into brown fat and release heat
8
Q
Brown fat
A
- Multilocular
- Smaller lipid droplets
- Rich in mitochondria
- Near blood vessels
- Contain cytochrome pigment
9
Q
Brown fat principal function
A
- Heat production
- Tissue is subdivided into LOBULEs
- receive direct innervation from sympathetic
10
Q
Nonshivering thermogenesis
A
- nerves release NE into brown adi
- NE activates hormone sensitive lipase
- liberated FA are metabolized which gives off heat
11
Q
Thermogenin
A
- protein in inner mitochondrial membranes of brown adi
- in presence of FFA, thermogenin allows H+ to flow from the intermembranous space to the matrix without passing through ATP syn
- H+ flow dissipates as heat
12
Q
Leptin
A
Released from white adipocytes
-Targets hypothalamus to regulate appetite
13
Q
Adipocytes can release this harmful thing
A
-Proinflammatory cytokines
