Carlsson Flashcards
what is hyperdopaminergia
too much of nt dopamine
what is hypoglutamatergia
too little of nt glutamate
aim of carlsson
review studies that look at relationship between nt & sz
look at effectiveness of drug treatment for sz
method of carlsson
reviewing 32 studies in total, 8 animal, 5 drugs, 12 brain scans, 7 other.
looking at different levels of severity
conducted a review of the studies
results of carlsson
- link between dopamine and sz but varies between patients
- not just dopamine other nt are associated e.g. serotonin, GABA
- low glutamate = high dopamine = sz symptoms
- PCP lowers glutamate which increases psychosis symptoms
- brain areas associated with sz include basal ganglia and cerebral cortex
- clozapine an atypical antipsychotic is very effective and has minimal side effects compared to others
conclusion of carlsson
- clozapine is best so should be used
- dopamine/glutamine are associated with sz but more research needs to be done on other nt
evaluate carlsson in terms of generalisability
:( lots of animal studies not representative of sz in humans
:) uses a variety of studies e.g. animal, brain scans -> more representative of role of nt as looking at lots of settings
evaluate carlsson in terms of reliability
:) secondary data is reliable because it is already published so researcher can go through findings as many times as needed
evaluate carlsson in terms of applications
:) useful as we know which drugs should be prescribed -> clozapine is best which is useful to ensure patient gets best treatment
evaluate carlsson in terms of validity
:( secondary data -> may be biased as researcher may have chosen studies that fit aim
:( temporal validity may be low as published results may use outdated diagnosis manual less valid as wont represent sz today
:( some studies look at parkinsons -> less representative of sz as not directly studying it
