Carla - Introduction to the Cell Cycle Flashcards

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1
Q

What does the length of a cells life depend on?

A

The type of cell they are e.g. epithelia live for a short amount of time

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2
Q

How long do rbcs live for?

A

120 days

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3
Q

What is cell division?

A

The process by which new cells are made

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4
Q

What is mitosis?

A

Cell replication leading to division
Identical clones

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5
Q

Give three reasons why cells divide

A

Growth

Replace old cells

Replenish low numbers

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6
Q

What occurs when growth happens by accident?

A

Tumours are formed

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7
Q

What happens as cells age?
(3)

A

They get worn out

They become not as good at carrying out their function

Accidental mutations can occur

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8
Q

When might cells have to be replaced?
(2)

A

If cells have burst

If cells are damaged

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9
Q

What is required for cell division?

A

Cell signalling -> it is a very carefully regulated event

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10
Q

What must first be done before replication?
(4)

A

All the components required to make a new cell must be made

Genetic material must be copied

Identical copy of each chromosome must be made

All cell components

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11
Q

Explain how cell replication and division happens
(9)

A

Strands of DNA become more tightly packed into a condensed form

The parent and copy remain attached to each other in the one place

The membrane around the nucleus then breaks down

The chromosomes line up across the centre of the cell

The parent and copy then separate

The individual chromosomes move to opposite sides of the cell

The cell membrane begins to pinch inwards

Genetic information is enclosed in new nuclear membranes in parent and daughter

The chromosomes uncoil and turn into long threads of DNA again

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12
Q

How many phases are there to cell replication?

A

Two main phases
- interphase
- mitotic phase (M phase)

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13
Q

What happens in interphase?

A

The cell grows and makes a copy of its DNA

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14
Q

What happens in the mitotic phase?

A

The cell separates its duplicated DNA into two sets and divides its cytoplasm forming two new cells

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15
Q

How many stages are there to mitosis?

A

Five

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16
Q

What are the five stages to mitosis?

A

Prophase
Metaphase
Anaphase
Telophase
Cytokinesis

17
Q

What comes before mitosis?

A

Interphase

18
Q

How many pauses are there in the cell cycle?

A

Three

19
Q

What are the three phases to interphase?

A

G1 phase
S phase
G2 phase

20
Q

What is the G1 phase?
(2)

A

This is the cell growth phase - prep phase

Cellular contents excluding the chromosomes are duplicated

21
Q

What is the S phase?

A

Each of the 46 chromosomes are duplicated by the cell

22
Q

What is the G2 phase?

A

The cell double checks the duplicated chromosomes for errors and makes any necessary repairs

23
Q

List in the correct order the phases of the cell cycle

A

Interphase (G1, S, G2 phases)

Mitosis (Prophase, Metaphase, Anaphase, Telophase, Cytokinesis)

24
Q

How many chechpoints are there in the cell cycle?

A

Three

25
Q

Name the three checkpoints of the cell cycle

A

G1 checkpoint
G2 checkpoint
M checkpoint

26
Q

What happens at the G1 checkpoint?
(5)

A

The cell decides whether or not to divide

Cell checks for:
- size
- nutrients
- growth factors
- DNA damage

27
Q

What happens if the cell passes the G1 checkpoint?

A

The cell enters the S phase

28
Q

What happens if the cell doesn’t pass the G1 phase?

A

It enters the resting state (G0 phase)

29
Q

What happens at the G2 checkpoint?

A

Double checks the DNA
Is there any errors - can they be fixed
If there is unfixable errors the cell does not go on to mitosis -> apoptosis

30
Q

Give the four dyes used to stain cells

A

Green stain fluorescent -> binds actively replicating DNA (S)

Red stain fluorescent propidium iodide (PI) -> binds DNA

Yellow stain fluorescent -> binds over lapping cells

31
Q

Who discovered cells could divide?

A

Walter flemming