Cardiovascular Drugs 1 Flashcards by Jhaunte Braithwaite

Q

Where does water and ion exchange occur?

A

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Q

What does the glomerulus exchange?

A

Extremely high water solubility

No primary transporters & drug targets

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Q

What does the proximal tubule exchange?

A

Water solubility: high

Primary transporters & drug targets: Na+/H+ (NHE3), carbonic anhydrase, acid and base transporters

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Q

What does the thin descending loop of henle exchange?

A

Water permeability: high

Primary transporters & drug targets: aquaporins

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Q

What are function of the thick ascending loop of henle?

A

Water permeability: very low

Primary transporters & drug targets: Na+/K+/2Cl- (NKCC2)

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Q

What is the function of the distal convuluted tubule?

A

Very low water solubility

Primary transporter/drug target: Na+/Cl(NCC)

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Q

What is the function of the cortical collecting duct?

A

Variable water solubility

Primary transporters & drug targets: ENaC, K+ channels, H+ transporter, aqua porins

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Q

When do we need a diuretic?

A

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Q

What are edematous states?

A

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Q

What are non-edematous states?

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Q

What are the diuretics? What are there main uses?

A

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Q

What are the main loop diuretics?

A

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Q

What are the main thiazide diuretics?

A

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Q

What are the potassium-sparing diuretics?

A

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Q

What are the main carbonic anhydrase inhibitors?

A

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Q

What are the main osmotic agents?

A

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Q

What is the main ADH antagonist?

A

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Q

What are the main sites of action of diuretics?

A

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Q

Describe loop diuretics

A

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Q

What is the mechanism of action of loop diuretics?

A

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Q

What are the actions of loop diuretics?

A

Q

What are the adverse effects of loop diuretics?

A

Q

Summarize loop diuretics effects

A

Q

What are the clinical applications of thiazides?

A

What is the mechanism of action of thiazides?

What are the actions of thiazides?

What are the adverse effects of thiazides?

What are K+-Sparing- aldosterone antagonists ?

What are the clinical applications of K+-sparing-aldosterone antagonists ?

What are the mechanisms of action of K+-sparing diuretics-aldosterone antagonist?

What are the adverse effects of K+-Sparing diuretics-aldosterone antagonists ?

What are K+- sparing Na+ channel inhibitors ?

What is the mechanism of action of K+-sparing Na+- Channel inhibitors ?

What are the adverse effects of K+-sparing Na+ Channel inhibitors?

Describe the summary of K+-sparing

What are carbonic anhydrase inhibitors?

What were the clinical applications of carbonic anhydrase?

What is the mechanism of action of CA inhibitors?

Describe the PK of CA inhibitors

Describe the adverse effects of CA inhibitors

Give a summary on CA inhibitors

What are osmotic diuretics?

What are the clinical applications of osmotic diuretics ?

What is the PK of osmotic diuretics?

What are the adverse effects/contraindications of osmotic diuretics?

What are ADH Antagonists?

What is the mechanism of action of ADH Antagonists?

What are the clinical applications of ADH Antagonists?

What are the PK of ADH antagonists?

What are the adverse effects of ADH Antagonists?

What are the contraindications of ADH antagonists?

Summarize antagonists