Cardiovascular Disorders Flashcards
Where do Atheromatous lesions and subsequent occlusion usually occur?
- Vessel Bifurcations
* Decreased lumen diameter (narrowings)
Steps that cause Atherosclerosis
- Damage to the endothelial cells from mechanical/chemical/inflammation
- Platelet adhesion and clotting
- Smooth muscle cells move from middle layer into lining
- Muscle cells form atheroma in lining
- Atheroma become fibrous and hard
- Vessel narrowed
What can cause deep inflammation?
Chronic gum disease
Lingering UTI’s
Others
How does deep inflammation cause MI’s?
Weakens blood vessels which causes fatty buildups to burst
How can inflammation in patients at risk for heart disease be tested?
- Testing blood for elevated WBC
* Measuring C-reactive protein level
What is C-reactive protein?
A chemical in the blood necessary for fighting injury and infection
Two names for the plaque in Atherosclerosis
- Atheromata
* Atheromatous Lesions
How can C-reactive protein be lowered?
- cholesterol-lowering drugs
- aspirin
- diet/exercise
What are two major effects atherosclerosis has on blood vessels?
- Disrupts inner most lining causing loss of elasticity and increase in formation of clots
- Reduces diameter of vessel lumen
What causes angina?
Imbalance between myocardial O2 demand and supply
Imbalance between myocardial O2 demand and supply causes a buildup of what?
CO2
Lactic Acid
What does a buildup of metabolites (CO2 & lactic acid) in ischemic tissues cause?
Irritates nerve endings and produces anginal pain
What is the most common cause of angina pectoris?
Atherosclerotic disease of coronary arteries
A temporary occlusion caused by vasospasm of a coronary artery with or without atherosclerosis
Prinzmetal’s Angina
What does an I.V. do for the heart?
Increases preload
What creates most dysrhythmias?
Hypoxia
-decreased heart perfusion
Is a bounding pulse fast or slow?
Slow
-increased preload=decreased rate
What are some characteristics of prinzmental’s angina?
- often has ST elevation
- resistant to TX (NTG)
- pain > 10min.
- looks like an MI
- aka “Unstable Angina” or “Preinfarction Angina”
Tachypnea Tachycardia Pale, cool, clammy Delayed cap refill Hypotension ALOC
S/S of decreased Cardiac Output
O- sudden P-exercise, activity stress, big meal Q- pressure, tightness, weight, burn R- substernal, epigastric, may radiate to jaw, neck, shoulder or arm S- mild or moderate T- 3-5 min., rarely past 10min.
Angina Pectoris
Angina Pectoris TX
Calm/ reassure (⬇️O2 demand)
POC
O2 (if
How is stable angina relieved?
Rest
02
NTG
Name some associated S/S of angina
- Anxiety
- SOB
- N/V
- Diaphoresis
What layer does atherosclerotic plaque found?
Tunica Intima